A supramolecular fluorine magnetic resonance spectroscopy probe polymer based on Passerini bifunctional monomer

Research output: Contribution to journalArticlepeer-review

Standard

A supramolecular fluorine magnetic resonance spectroscopy probe polymer based on Passerini bifunctional monomer. / O'Reilly, Rachel; Couturaud, Benoit; Houston, Zachary H; Cowin, Gary J; Prokes, Ivan; Foster, Jeff; Thurecht, Kristofer J.

In: ACS Macro Letters, Vol. 8, No. 11, 15.10.2019, p. 1479.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

O'Reilly, Rachel ; Couturaud, Benoit ; Houston, Zachary H ; Cowin, Gary J ; Prokes, Ivan ; Foster, Jeff ; Thurecht, Kristofer J. / A supramolecular fluorine magnetic resonance spectroscopy probe polymer based on Passerini bifunctional monomer. In: ACS Macro Letters. 2019 ; Vol. 8, No. 11. pp. 1479.

Bibtex

@article{25b25c13c4ff4a6cbfbc1e7c829581a4,
title = "A supramolecular fluorine magnetic resonance spectroscopy probe polymer based on Passerini bifunctional monomer",
abstract = "A water soluble fluorine Magnetic Resonance spectroscopy host-guest probe, P(HPA-co-AdamCF3A), was successfully constructed using facile chemistries to synthesize a novel bifunctional monomer via a quantitative Passerini reaction. Supramolecular complexation with (2-hydroxypropyl)-β-cyclodextrin promoted a change in the chemical environment leading to modulationof both the relaxation properties as well as chemical shift of the fluorine moieties. This change was used to probe the supramolecularinteraction by 19F MRI spectroscopy and give new insight on fluorine probe formulation. This work provides a fundamental basis fora 19F MRimaging tracer capable of assessing host-guest inclusion and a potential model to follow the fate of a drug delivery system invivo.",
keywords = "water soluble fluorine, bifunctional monomer, Passerini reaction, Supramolecular complexation, host-guest chemistry",
author = "Rachel O'Reilly and Benoit Couturaud and Houston, {Zachary H} and Cowin, {Gary J} and Ivan Prokes and Jeff Foster and Thurecht, {Kristofer J.}",
year = "2019",
month = oct,
day = "15",
doi = "https://doi.org/10.1021/acsmacrolett.9b00626",
language = "English",
volume = "8",
pages = "1479",
journal = "ACS Macro Letters",
issn = "2161-1653",
publisher = "American Chemical Society",
number = "11",

}

RIS

TY - JOUR

T1 - A supramolecular fluorine magnetic resonance spectroscopy probe polymer based on Passerini bifunctional monomer

AU - O'Reilly, Rachel

AU - Couturaud, Benoit

AU - Houston, Zachary H

AU - Cowin, Gary J

AU - Prokes, Ivan

AU - Foster, Jeff

AU - Thurecht, Kristofer J.

PY - 2019/10/15

Y1 - 2019/10/15

N2 - A water soluble fluorine Magnetic Resonance spectroscopy host-guest probe, P(HPA-co-AdamCF3A), was successfully constructed using facile chemistries to synthesize a novel bifunctional monomer via a quantitative Passerini reaction. Supramolecular complexation with (2-hydroxypropyl)-β-cyclodextrin promoted a change in the chemical environment leading to modulationof both the relaxation properties as well as chemical shift of the fluorine moieties. This change was used to probe the supramolecularinteraction by 19F MRI spectroscopy and give new insight on fluorine probe formulation. This work provides a fundamental basis fora 19F MRimaging tracer capable of assessing host-guest inclusion and a potential model to follow the fate of a drug delivery system invivo.

AB - A water soluble fluorine Magnetic Resonance spectroscopy host-guest probe, P(HPA-co-AdamCF3A), was successfully constructed using facile chemistries to synthesize a novel bifunctional monomer via a quantitative Passerini reaction. Supramolecular complexation with (2-hydroxypropyl)-β-cyclodextrin promoted a change in the chemical environment leading to modulationof both the relaxation properties as well as chemical shift of the fluorine moieties. This change was used to probe the supramolecularinteraction by 19F MRI spectroscopy and give new insight on fluorine probe formulation. This work provides a fundamental basis fora 19F MRimaging tracer capable of assessing host-guest inclusion and a potential model to follow the fate of a drug delivery system invivo.

KW - water soluble fluorine

KW - bifunctional monomer

KW - Passerini reaction

KW - Supramolecular complexation

KW - host-guest chemistry

U2 - https://doi.org/10.1021/acsmacrolett.9b00626

DO - https://doi.org/10.1021/acsmacrolett.9b00626

M3 - Article

VL - 8

SP - 1479

JO - ACS Macro Letters

JF - ACS Macro Letters

SN - 2161-1653

IS - 11

ER -