A supramolecular fluorine magnetic resonance spectroscopy probe polymer based on Passerini bifunctional monomer
Research output: Contribution to journal › Article › peer-review
Authors
Colleges, School and Institutes
External organisations
- The University of Queensland
- Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK.
- University of Queensland
- ARC Centre of Excellence in Convergent Bio-Nano Science and Technology
Abstract
A water soluble fluorine Magnetic Resonance spectroscopy host-guest probe, P(HPA-co-AdamCF3A), was successfully constructed using facile chemistries to synthesize a novel bifunctional monomer via a quantitative Passerini reaction. Supramolecular complexation with (2-hydroxypropyl)-β-cyclodextrin promoted a change in the chemical environment leading to modulation
of both the relaxation properties as well as chemical shift of the fluorine moieties. This change was used to probe the supramolecular
interaction by 19F MRI spectroscopy and give new insight on fluorine probe formulation. This work provides a fundamental basis for
a 19F MRimaging tracer capable of assessing host-guest inclusion and a potential model to follow the fate of a drug delivery system in
vivo.
of both the relaxation properties as well as chemical shift of the fluorine moieties. This change was used to probe the supramolecular
interaction by 19F MRI spectroscopy and give new insight on fluorine probe formulation. This work provides a fundamental basis for
a 19F MRimaging tracer capable of assessing host-guest inclusion and a potential model to follow the fate of a drug delivery system in
vivo.
Details
| Original language | English |
|---|---|
| Pages (from-to) | 1479 |
| Number of pages | 5 |
| Journal | ACS Macro Letters |
| Volume | 8 |
| Issue number | 11 |
| Publication status | Published - 15 Oct 2019 |
Keywords
- water soluble fluorine, bifunctional monomer, Passerini reaction, Supramolecular complexation, host-guest chemistry