A supramolecular fluorine magnetic resonance spectroscopy probe polymer based on Passerini bifunctional monomer

Research output: Contribution to journalArticlepeer-review


  • Zachary H Houston
  • Gary J Cowin
  • Ivan Prokes
  • Kristofer J. Thurecht

Colleges, School and Institutes

External organisations

  • The University of Queensland
  • The University of Warwick
  • ARC Centre of Excellence in Convergent Bio-Nano Science and Technology


A water soluble fluorine Magnetic Resonance spectroscopy host-guest probe, P(HPA-co-AdamCF3A), was successfully constructed using facile chemistries to synthesize a novel bifunctional monomer via a quantitative Passerini reaction. Supramolecular complexation with (2-hydroxypropyl)-β-cyclodextrin promoted a change in the chemical environment leading to modulation
of both the relaxation properties as well as chemical shift of the fluorine moieties. This change was used to probe the supramolecular
interaction by 19F MRI spectroscopy and give new insight on fluorine probe formulation. This work provides a fundamental basis for
a 19F MRimaging tracer capable of assessing host-guest inclusion and a potential model to follow the fate of a drug delivery system in


Original languageEnglish
Pages (from-to)1479
Number of pages5
JournalACS Macro Letters
Issue number11
Publication statusPublished - 15 Oct 2019


  • water soluble fluorine, bifunctional monomer, Passerini reaction, Supramolecular complexation, host-guest chemistry