A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

Research output: Contribution to journalArticlepeer-review

Standard

A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue. / Rana, Batika M J; Jou, Eric; Barlow, Jillian L; Rodriguez-Rodriguez, Noe; Walker, Jennifer A; Knox, Claire; Jolin, Helen E; Hardman, Clare S; Sivasubramaniam, Meera; Szeto, Aydan; Cohen, E Suzanne; Scott, Ian C; Sleeman, Matthew A; Chidomere, Chiamaka I; Cruz Migoni, Sara; Caamano, Jorge; Jorgensen, Helle F; Carobbio, Stefania; Vidal-Puig, Antonio; McKenzie, Andrew N J.

In: The Journal of Experimental Medicine, Vol. 216, No. 9, 02.09.2019, p. 1999-2009.

Research output: Contribution to journalArticlepeer-review

Harvard

Rana, BMJ, Jou, E, Barlow, JL, Rodriguez-Rodriguez, N, Walker, JA, Knox, C, Jolin, HE, Hardman, CS, Sivasubramaniam, M, Szeto, A, Cohen, ES, Scott, IC, Sleeman, MA, Chidomere, CI, Cruz Migoni, S, Caamano, J, Jorgensen, HF, Carobbio, S, Vidal-Puig, A & McKenzie, ANJ 2019, 'A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue', The Journal of Experimental Medicine, vol. 216, no. 9, pp. 1999-2009. https://doi.org/10.1084/jem.20190689

APA

Rana, B. M. J., Jou, E., Barlow, J. L., Rodriguez-Rodriguez, N., Walker, J. A., Knox, C., Jolin, H. E., Hardman, C. S., Sivasubramaniam, M., Szeto, A., Cohen, E. S., Scott, I. C., Sleeman, M. A., Chidomere, C. I., Cruz Migoni, S., Caamano, J., Jorgensen, H. F., Carobbio, S., Vidal-Puig, A., & McKenzie, A. N. J. (2019). A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue. The Journal of Experimental Medicine, 216(9), 1999-2009. https://doi.org/10.1084/jem.20190689

Vancouver

Rana BMJ, Jou E, Barlow JL, Rodriguez-Rodriguez N, Walker JA, Knox C et al. A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue. The Journal of Experimental Medicine. 2019 Sep 2;216(9):1999-2009. https://doi.org/10.1084/jem.20190689

Author

Rana, Batika M J ; Jou, Eric ; Barlow, Jillian L ; Rodriguez-Rodriguez, Noe ; Walker, Jennifer A ; Knox, Claire ; Jolin, Helen E ; Hardman, Clare S ; Sivasubramaniam, Meera ; Szeto, Aydan ; Cohen, E Suzanne ; Scott, Ian C ; Sleeman, Matthew A ; Chidomere, Chiamaka I ; Cruz Migoni, Sara ; Caamano, Jorge ; Jorgensen, Helle F ; Carobbio, Stefania ; Vidal-Puig, Antonio ; McKenzie, Andrew N J. / A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue. In: The Journal of Experimental Medicine. 2019 ; Vol. 216, No. 9. pp. 1999-2009.

Bibtex

@article{a3855aa6a8a84fd58fb4294955ba3d42,
title = "A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue",
abstract = "Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.",
author = "Rana, {Batika M J} and Eric Jou and Barlow, {Jillian L} and Noe Rodriguez-Rodriguez and Walker, {Jennifer A} and Claire Knox and Jolin, {Helen E} and Hardman, {Clare S} and Meera Sivasubramaniam and Aydan Szeto and Cohen, {E Suzanne} and Scott, {Ian C} and Sleeman, {Matthew A} and Chidomere, {Chiamaka I} and {Cruz Migoni}, Sara and Jorge Caamano and Jorgensen, {Helle F} and Stefania Carobbio and Antonio Vidal-Puig and McKenzie, {Andrew N J}",
year = "2019",
month = sep,
day = "2",
doi = "10.1084/jem.20190689",
language = "English",
volume = "216",
pages = "1999--2009",
journal = "The Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "9",

}

RIS

TY - JOUR

T1 - A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

AU - Rana, Batika M J

AU - Jou, Eric

AU - Barlow, Jillian L

AU - Rodriguez-Rodriguez, Noe

AU - Walker, Jennifer A

AU - Knox, Claire

AU - Jolin, Helen E

AU - Hardman, Clare S

AU - Sivasubramaniam, Meera

AU - Szeto, Aydan

AU - Cohen, E Suzanne

AU - Scott, Ian C

AU - Sleeman, Matthew A

AU - Chidomere, Chiamaka I

AU - Cruz Migoni, Sara

AU - Caamano, Jorge

AU - Jorgensen, Helle F

AU - Carobbio, Stefania

AU - Vidal-Puig, Antonio

AU - McKenzie, Andrew N J

PY - 2019/9/2

Y1 - 2019/9/2

N2 - Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.

AB - Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.

UR - http://www.scopus.com/inward/record.url?scp=85071635520&partnerID=8YFLogxK

U2 - 10.1084/jem.20190689

DO - 10.1084/jem.20190689

M3 - Article

C2 - 31248899

VL - 216

SP - 1999

EP - 2009

JO - The Journal of Experimental Medicine

JF - The Journal of Experimental Medicine

SN - 0022-1007

IS - 9

ER -