TY - JOUR
T1 - A stromal address code defined by fibroblasts
AU - Parsonage, Gregory
AU - Filer, Andrew
AU - Haworth, Oliver
AU - Nash, Gerard
AU - Rainger, George
AU - Salmon, Michael
AU - Buckley, Christopher
PY - 2005/1/1
Y1 - 2005/1/1
N2 - To navigate into and within tissues, leukocytes require guidance cues that enable them to recognize which tissues to enter and which to avoid. Such cues are partly provided at the time of extravasation from blood by an endothelial address code on the luminal surface of the vascular endothelium. Here, we review the evidence that fibroblasts help define an additional stromal address code that directs leukocyte behaviour within tissues. We examine how this stromal code regulates site-specific leukocyte accumulation, differentiation and survival in a variety of physiological stromal niches, and how the aberrant expression of components of this code in the wrong tissue at the wrong time contributes to the persistence of chronic inflammatory diseases.
AB - To navigate into and within tissues, leukocytes require guidance cues that enable them to recognize which tissues to enter and which to avoid. Such cues are partly provided at the time of extravasation from blood by an endothelial address code on the luminal surface of the vascular endothelium. Here, we review the evidence that fibroblasts help define an additional stromal address code that directs leukocyte behaviour within tissues. We examine how this stromal code regulates site-specific leukocyte accumulation, differentiation and survival in a variety of physiological stromal niches, and how the aberrant expression of components of this code in the wrong tissue at the wrong time contributes to the persistence of chronic inflammatory diseases.
UR - http://www.scopus.com/inward/record.url?scp=14644404221&partnerID=8YFLogxK
U2 - 10.1016/j.it.2004.11.014
DO - 10.1016/j.it.2004.11.014
M3 - Review article
C2 - 15745857
SN - 1471-4981
VL - 26
SP - 150
EP - 156
JO - Trends in Immunology
JF - Trends in Immunology
IS - 3
ER -