A stromal address code defined by fibroblasts

Research output: Contribution to journalReview articlepeer-review

Abstract

To navigate into and within tissues, leukocytes require guidance cues that enable them to recognize which tissues to enter and which to avoid. Such cues are partly provided at the time of extravasation from blood by an endothelial address code on the luminal surface of the vascular endothelium. Here, we review the evidence that fibroblasts help define an additional stromal address code that directs leukocyte behaviour within tissues. We examine how this stromal code regulates site-specific leukocyte accumulation, differentiation and survival in a variety of physiological stromal niches, and how the aberrant expression of components of this code in the wrong tissue at the wrong time contributes to the persistence of chronic inflammatory diseases.

Details

Original languageEnglish
Pages (from-to)150-6
Number of pages7
JournalTrends in Immunology
Volume26
Issue number3
Publication statusPublished - 1 Jan 2005