A sibling-pair analysis of fasting lipids and anthropometric measurements and their relationship to hypertension

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A sibling-pair analysis of fasting lipids and anthropometric measurements and their relationship to hypertension. / Thomas, G N; Young, R P; Tomlinson, B; Anderson, P J; Woo, K S; Sanderson, J E; Critchley, J A.

In: Clinical and Experimental Hypertension, Vol. 21, No. 7, 10.1999, p. 1161-76.

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@article{2cf42fad8332482fa4bd61a15609c9e6,
title = "A sibling-pair analysis of fasting lipids and anthropometric measurements and their relationship to hypertension",
abstract = "Fifty non-diabetic, young Chinese hypertensives were compared to their normotensive siblings with respect to body fat distribution and fasting lipid and glucose (FPG) profiles. Sitting BP in hypertensives met conventional hypertension criteria after a 4-week washout period on placebo. Hypertensives had greater body mass index (BMI), subscapular skin-fold thickness (SFT), waist circumference (W), waist-to-height (WHtR) and waist-to-hip ratio (WHR), p<0.0001 for all. Higher triglycerides (p=0.004) and lower HDL-cholesterol (p=0.015) concentrations were also observed. Weight, W, WHtR and BMI were higher in hypertensives in both male (n=9) and female gender-concordant sibling pairs (n=21). Higher WHR, hip circumference and subscapular SFT were only seen in the male hypertensives. Hypertension is associated with central adiposity and adverse lipid profiles in this group of young hypertensives, supporting the hypothesis that obesity, particularly central, is closely associated with hypertension in Chinese as in other ethnic groups.",
keywords = "Adult, Anthropometry, Asian Continental Ancestry Group, Biomarkers, Blood Pressure, Fasting, Female, Hong Kong, Humans, Hypertension, Lipids, Male, Middle Aged, Nuclear Family, Obesity",
author = "Thomas, {G N} and Young, {R P} and B Tomlinson and Anderson, {P J} and Woo, {K S} and Sanderson, {J E} and Critchley, {J A}",
year = "1999",
month = oct,
language = "English",
volume = "21",
pages = "1161--76",
journal = "Clinical and Experimental Hypertension",
issn = "1064-1963",
publisher = "Taylor & Francis",
number = "7",

}

RIS

TY - JOUR

T1 - A sibling-pair analysis of fasting lipids and anthropometric measurements and their relationship to hypertension

AU - Thomas, G N

AU - Young, R P

AU - Tomlinson, B

AU - Anderson, P J

AU - Woo, K S

AU - Sanderson, J E

AU - Critchley, J A

PY - 1999/10

Y1 - 1999/10

N2 - Fifty non-diabetic, young Chinese hypertensives were compared to their normotensive siblings with respect to body fat distribution and fasting lipid and glucose (FPG) profiles. Sitting BP in hypertensives met conventional hypertension criteria after a 4-week washout period on placebo. Hypertensives had greater body mass index (BMI), subscapular skin-fold thickness (SFT), waist circumference (W), waist-to-height (WHtR) and waist-to-hip ratio (WHR), p<0.0001 for all. Higher triglycerides (p=0.004) and lower HDL-cholesterol (p=0.015) concentrations were also observed. Weight, W, WHtR and BMI were higher in hypertensives in both male (n=9) and female gender-concordant sibling pairs (n=21). Higher WHR, hip circumference and subscapular SFT were only seen in the male hypertensives. Hypertension is associated with central adiposity and adverse lipid profiles in this group of young hypertensives, supporting the hypothesis that obesity, particularly central, is closely associated with hypertension in Chinese as in other ethnic groups.

AB - Fifty non-diabetic, young Chinese hypertensives were compared to their normotensive siblings with respect to body fat distribution and fasting lipid and glucose (FPG) profiles. Sitting BP in hypertensives met conventional hypertension criteria after a 4-week washout period on placebo. Hypertensives had greater body mass index (BMI), subscapular skin-fold thickness (SFT), waist circumference (W), waist-to-height (WHtR) and waist-to-hip ratio (WHR), p<0.0001 for all. Higher triglycerides (p=0.004) and lower HDL-cholesterol (p=0.015) concentrations were also observed. Weight, W, WHtR and BMI were higher in hypertensives in both male (n=9) and female gender-concordant sibling pairs (n=21). Higher WHR, hip circumference and subscapular SFT were only seen in the male hypertensives. Hypertension is associated with central adiposity and adverse lipid profiles in this group of young hypertensives, supporting the hypothesis that obesity, particularly central, is closely associated with hypertension in Chinese as in other ethnic groups.

KW - Adult

KW - Anthropometry

KW - Asian Continental Ancestry Group

KW - Biomarkers

KW - Blood Pressure

KW - Fasting

KW - Female

KW - Hong Kong

KW - Humans

KW - Hypertension

KW - Lipids

KW - Male

KW - Middle Aged

KW - Nuclear Family

KW - Obesity

M3 - Article

C2 - 10513834

VL - 21

SP - 1161

EP - 1176

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

SN - 1064-1963

IS - 7

ER -