A risk model for congenital syphilis in infants born to mothers with syphilis treated in gestation: a prospective cohort study

Research output: Contribution to journalArticle


  • J Liu
  • FC Hong
  • P Pan
  • H Zhou
  • F Yang
  • YM Cai
  • LZ Wen
  • YH Lai
  • LJ Lin


OBJECTIVE: To explore the risk factors underlying congenital syphilis (CS) and to build a hazards model to assess the risk of CS in offspring born to mothers with syphilis treated in gestation. METHODS: This prospective study observed 554 pregnant women with syphilis and their offspring recruited from August 2002 to May 2007 in Shenzhen Centre for Chronic Disease Control and Prevention. After treatment, all the women were followed up until the diagnosis of CS in their offspring was confirmed or denied. Comparisons were made between women bearing infants with CS and women bearing infants without CS to reveal the risk factors for CS. ORs and their 95% CI were calculated for each risk factor by using logistical regression analysis. RESULTS: Twenty-nine (5.2%) infants were diagnosed with CS. Univariable analyses showed that the reciprocal logarithm of the titre of non-treponemal antibodies in mothers (log (1/T); OR=11.18, p


Original languageEnglish
Pages (from-to)292-296
Number of pages5
JournalSexually Transmitted Infections
Issue number4
Publication statusPublished - 1 Aug 2010