A review of salivary gland histopathology in primary Sjögren's syndrome with a focus on its potential as a clinical trials biomarker

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@article{701afeceecae494d969fdd0d658e7ba6,
title = "A review of salivary gland histopathology in primary Sj{\"o}gren's syndrome with a focus on its potential as a clinical trials biomarker",
abstract = "Salivary gland changes, characterised by a focal lymphocytic sialadenitits, play an important role in the diagnosis of primary Sj{\"o}gren's syndrome (PSS) and were first described over 40 years ago. Recent evidence suggests that minor salivary gland biopsy may also provide information useful for prognostication and stratification, yet difficulties may arise in the histopathological interpretation and scoring, and evidence exists that reporting is variable. With the increasing number of actual and proposed clinical trials in PSS, we review the evidence that might support the role of histopathology as a biomarker for stratification and response to therapy and highlight areas where further validation work is required.",
author = "Fisher, {Benjamin A} and Brown, {Rachel M} and Bowman, {Simon J} and Francesca Barone",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",
year = "2015",
month = sep,
doi = "10.1136/annrheumdis-2015-207499",
language = "English",
volume = "74",
pages = "1645--50",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",
number = "9",

}

RIS

TY - JOUR

T1 - A review of salivary gland histopathology in primary Sjögren's syndrome with a focus on its potential as a clinical trials biomarker

AU - Fisher, Benjamin A

AU - Brown, Rachel M

AU - Bowman, Simon J

AU - Barone, Francesca

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2015/9

Y1 - 2015/9

N2 - Salivary gland changes, characterised by a focal lymphocytic sialadenitits, play an important role in the diagnosis of primary Sjögren's syndrome (PSS) and were first described over 40 years ago. Recent evidence suggests that minor salivary gland biopsy may also provide information useful for prognostication and stratification, yet difficulties may arise in the histopathological interpretation and scoring, and evidence exists that reporting is variable. With the increasing number of actual and proposed clinical trials in PSS, we review the evidence that might support the role of histopathology as a biomarker for stratification and response to therapy and highlight areas where further validation work is required.

AB - Salivary gland changes, characterised by a focal lymphocytic sialadenitits, play an important role in the diagnosis of primary Sjögren's syndrome (PSS) and were first described over 40 years ago. Recent evidence suggests that minor salivary gland biopsy may also provide information useful for prognostication and stratification, yet difficulties may arise in the histopathological interpretation and scoring, and evidence exists that reporting is variable. With the increasing number of actual and proposed clinical trials in PSS, we review the evidence that might support the role of histopathology as a biomarker for stratification and response to therapy and highlight areas where further validation work is required.

U2 - 10.1136/annrheumdis-2015-207499

DO - 10.1136/annrheumdis-2015-207499

M3 - Article

C2 - 26034044

VL - 74

SP - 1645

EP - 1650

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 9

ER -