A review of biophysiological and biochemical indicators of stress for connected and preventive healthcare

Research output: Contribution to journalArticlepeer-review


  • Talha Iqbal
  • Adnan Elahi
  • Pau Redon
  • Patricia Vazquez
  • William Wijns

Colleges, School and Institutes


Stress is a known contributor to several life-threatening medical conditions and a risk factor for triggering acute cardiovascular events, as well as a root cause of several social problems. The burden of stress is increasing globally and, with that, is the interest in developing effective stress-monitoring solutions for preventive and connected health, particularly with the help of wearable sensing technologies. The recent development of miniaturized and flexible biosensors has enabled the development of connected wearable solutions to monitor stress and intervene in time to prevent the progression of stress-induced medical conditions. This paper presents a review of the literature on different physiological and chemical indicators of stress, which are commonly used for quantitative assessment of stress, and the associated sensing technologies.


Original languageEnglish
Article number556
Number of pages30
Issue number3
Publication statusPublished - 19 Mar 2021


  • stress monitoring, biomarkers, biosensors, connected health, preventive healthcare, physiological measurement, biochemical measurement