A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

J Broichhagen; J A Frank; N R Johnston; R K Mitchell; K Šmid; P Marchetti; M Bugliani; G A Rutter; D Trauner; D J Hodson

doi:10.1039/c5cc01224d

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

J Broichhagen, J A Frank, N R Johnston, R K Mitchell, K Šmid, P Marchetti, M Bugliani, G A Rutter, D Trauner, D J Hodson

Medical and Dental Sciences

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Abstract

Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.

Original language	English
Pages (from-to)	6018-21
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	27
Early online date	26 Feb 2015
DOIs	https://doi.org/10.1039/c5cc01224d
Publication status	Published - 7 Apr 2015

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10.1039/c5cc01224d

Broichhagen_et_al_Red-shifted_photochromic_sulfonylurea_Chemical_Communications_2015_Post-Print
Final version of record published as above Checked December 2015
Accepted author manuscript, 698 KBLicence: None: All rights reserved

Cite this

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title = "A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function",

abstract = "Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.",

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AU - Broichhagen, J

AU - Frank, J A

AU - Johnston, N R

AU - Mitchell, R K

AU - Šmid, K

AU - Marchetti, P

AU - Bugliani, M

AU - Rutter, G A

AU - Trauner, D

AU - Hodson, D J

PY - 2015/4/7

Y1 - 2015/4/7

N2 - Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.

AB - Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.

U2 - 10.1039/c5cc01224d

DO - 10.1039/c5cc01224d

M3 - Article

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SP - 6018

EP - 6021

JO - Chemical Communications

JF - Chemical Communications

IS - 27

ER -

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

Abstract

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