A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

Research output: Contribution to journalArticle

Authors

  • J Broichhagen
  • J A Frank
  • N R Johnston
  • R K Mitchell
  • K Šmid
  • P Marchetti
  • M Bugliani
  • G A Rutter
  • D Trauner

Colleges, School and Institutes

Abstract

Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.

Details

Original languageEnglish
Pages (from-to)6018-21
Number of pages4
JournalChemical Communications
Volume51
Issue number27
Early online date26 Feb 2015
Publication statusPublished - 7 Apr 2015