A randomized double‐blind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilm‐induced gingivitis

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A randomized double‐blind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilm‐induced gingivitis. / Abdulkareem, Ali A.; Al Marah, Zaid A.; Abdulbaqi, Hayder R.; Alshaeli, Ali J.; Milward, Michael.

In: International Journal of Dental Hygiene, Vol. 18, No. 3, 01.08.2020, p. 268-277.

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@article{5007b55f69a1456cb25bda757236c4ce,
title = "A randomized double‐blind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilm‐induced gingivitis",
abstract = "Objectives: To investigate the antiplaque and antigingivitis efficacy in addition to evaluating side effects and subjects{\textquoteright} perceptions of three commercially available mouthwashes. Methods: This study was a double-blind, parallel, and short-term trial. A total of 75 dental students with biofilm-induced gingivitis were included in the final analysis of the current study. Clinical parameters (plaque index and bleeding on probing) and the staining effect were measured at baseline and after 7 days. In addition, a VAS-based assessment questionnaire was completed by the participants. Results: All interventions significantly reduced plaque scores, but chlorhexidine (CHX) had a significantly higher effect than the hyaluronic acid (HA) and antioxidant mouthwashes. However, all mouthwashes significantly reduced the total bleeding scores to <10% in 53% of the patients, compared to the baseline record. Additionally, teeth underwent shade changes in association with all interventions by the end of the study. Analysis of feedback about the mouthwashes showed that the participants seemed to prefer the HA mouthwash over the other mouthwashes. Conclusions: CHX remains the most effective antiplaque mouthwash although HA and antioxidants are as effective as CHX in reducing bleeding. In addition, based on its better acceptance by the participants, HA is potentially a good alternative to CHX.",
keywords = "chlorhexidine, dental biofilm, mouth rinse/wash, oral hygiene, staining",
author = "Abdulkareem, {Ali A.} and {Al Marah}, {Zaid A.} and Abdulbaqi, {Hayder R.} and Alshaeli, {Ali J.} and Michael Milward",
year = "2020",
month = aug,
day = "1",
doi = "10.1111/idh.12432",
language = "English",
volume = "18",
pages = "268--277",
journal = "International Journal of Dental Hygiene",
issn = "1601-5029",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - A randomized double‐blind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilm‐induced gingivitis

AU - Abdulkareem, Ali A.

AU - Al Marah, Zaid A.

AU - Abdulbaqi, Hayder R.

AU - Alshaeli, Ali J.

AU - Milward, Michael

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Objectives: To investigate the antiplaque and antigingivitis efficacy in addition to evaluating side effects and subjects’ perceptions of three commercially available mouthwashes. Methods: This study was a double-blind, parallel, and short-term trial. A total of 75 dental students with biofilm-induced gingivitis were included in the final analysis of the current study. Clinical parameters (plaque index and bleeding on probing) and the staining effect were measured at baseline and after 7 days. In addition, a VAS-based assessment questionnaire was completed by the participants. Results: All interventions significantly reduced plaque scores, but chlorhexidine (CHX) had a significantly higher effect than the hyaluronic acid (HA) and antioxidant mouthwashes. However, all mouthwashes significantly reduced the total bleeding scores to <10% in 53% of the patients, compared to the baseline record. Additionally, teeth underwent shade changes in association with all interventions by the end of the study. Analysis of feedback about the mouthwashes showed that the participants seemed to prefer the HA mouthwash over the other mouthwashes. Conclusions: CHX remains the most effective antiplaque mouthwash although HA and antioxidants are as effective as CHX in reducing bleeding. In addition, based on its better acceptance by the participants, HA is potentially a good alternative to CHX.

AB - Objectives: To investigate the antiplaque and antigingivitis efficacy in addition to evaluating side effects and subjects’ perceptions of three commercially available mouthwashes. Methods: This study was a double-blind, parallel, and short-term trial. A total of 75 dental students with biofilm-induced gingivitis were included in the final analysis of the current study. Clinical parameters (plaque index and bleeding on probing) and the staining effect were measured at baseline and after 7 days. In addition, a VAS-based assessment questionnaire was completed by the participants. Results: All interventions significantly reduced plaque scores, but chlorhexidine (CHX) had a significantly higher effect than the hyaluronic acid (HA) and antioxidant mouthwashes. However, all mouthwashes significantly reduced the total bleeding scores to <10% in 53% of the patients, compared to the baseline record. Additionally, teeth underwent shade changes in association with all interventions by the end of the study. Analysis of feedback about the mouthwashes showed that the participants seemed to prefer the HA mouthwash over the other mouthwashes. Conclusions: CHX remains the most effective antiplaque mouthwash although HA and antioxidants are as effective as CHX in reducing bleeding. In addition, based on its better acceptance by the participants, HA is potentially a good alternative to CHX.

KW - chlorhexidine

KW - dental biofilm

KW - mouth rinse/wash

KW - oral hygiene

KW - staining

UR - http://www.scopus.com/inward/record.url?scp=85082000665&partnerID=8YFLogxK

U2 - 10.1111/idh.12432

DO - 10.1111/idh.12432

M3 - Article

VL - 18

SP - 268

EP - 277

JO - International Journal of Dental Hygiene

JF - International Journal of Dental Hygiene

SN - 1601-5029

IS - 3

ER -