A randomised controlled trial to compare two methods of constraint-induced movement therapy to improve functional ability in the affected upper limb in pre-school children with hemiplegic cerebral palsy:: CATCH TRIAL

Pauline Christmas; Catherine Sackley; Maxwell Feltham; Carole Cummins

doi:10.1177/0269215518763512

A randomised controlled trial to compare two methods of constraint-induced movement therapy to improve functional ability in the affected upper limb in pre-school children with hemiplegic cerebral palsy: CATCH TRIAL

Pauline Christmas, Catherine Sackley, Maxwell Feltham, Carole Cummins

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

1030 Downloads (Pure)

Abstract

Objective: To determine the feasibility and short-termefficacy of caregiver-directed constraint-induced movement therapy to improveupper limb function in young children with hemiplegic cerebral palsy.

Design: Randomized controlled trial with masked assessment.

Setting: Community paediatric therapy services.

Subjects: Pre-school children with hemiplegic cerebralpalsy.

Interventions: Caregiver-directed constraint-inducedmovement therapy administered using either 24-hour short-arm restraint device(prolonged) or intermittent holding restraint during therapy (manual).

Main measures: Primary measures include Assisting Hand Assessment (AHA) at 10 weeks. Secondary measures include adverse events,Quality of Upper Extremity Skills Test and Pediatric Quality of Life Inventory.Feasibility measures include recruitment, retention, data completeness and adherence.

Results: About 62/81 (72%) of eligible patients in 16centres were randomized (prolonged restraint n = 30; manual restraint n = 32)with 97% retention at 10 weeks. The mean change at 10 weeks on the AHAlogit-based 0–100 unit was 9.0 (95% confidence interval (CI): 5.7, 12.4;P < 0.001) for prolonged restraint and 5.3 (95% CI: 1.3, 9.4; P = 0.01) formanual restraint with a mean group difference of 3.7 (95% CI: −1.5, 8.8;P = 0.156) (AHA smallest detectable difference = 5 units). No serious relatedadverse events were reported. There were no differences in secondary outcomes.More daily therapy was delivered with prolonged restraint (60 vs 30 minutes;P < 0.001). AHA data were complete at baseline and 10 weeks.

Conclusion: Caregiver-directed constraint-induced movement therapy is feasible and associated with improvement in upper limb function at 10 weeks. More therapy was delivered with prolonged than with manual restraint,warranting further testing of this intervention in a longer term trial

Original language	English
Pages (from-to)	1-10
Journal	Clinical Rehabilitation
Early online date	19 Mar 2018
DOIs	https://doi.org/10.1177/0269215518763512
Publication status	E-pub ahead of print - 19 Mar 2018

Keywords

Hemiplegic cerebral palsy
constraint induced movement therapy
upper limb rehabilitation
therapy
randomised controlled trial

Access to Document

10.1177/0269215518763512Licence: None: All rights reserved

Christmas_et_al_Randomised_controlled_trial_Clinical_Rehabilitation_2018
Article accepted for publication in Clinical Rehabilitation. (c) Sage 2018. Publication forthcoming. Checked 14.2.18 The final publication is available at Springer via http://doi.org/10.1177/0269215518763512
Accepted author manuscript, 545 KBLicence: None: All rights reserved

http://journals.sagepub.com/doi/full/10.1177/0269215518763512Licence: None: All rights reserved

Fingerprint

Dive into the research topics of 'A randomised controlled trial to compare two methods of constraint-induced movement therapy to improve functional ability in the affected upper limb in pre-school children with hemiplegic cerebral palsy: CATCH TRIAL'. Together they form a unique fingerprint.

Cite this

Christmas, P., Sackley, C., Feltham, M., & Cummins, C. (2018). A randomised controlled trial to compare two methods of constraint-induced movement therapy to improve functional ability in the affected upper limb in pre-school children with hemiplegic cerebral palsy: CATCH TRIAL. Clinical Rehabilitation, 1-10. Advance online publication. https://doi.org/10.1177/0269215518763512

@article{87ed97a1bcf4427f85f56d7e9de0cd79,

title = "A randomised controlled trial to compare two methods of constraint-induced movement therapy to improve functional ability in the affected upper limb in pre-school children with hemiplegic cerebral palsy:: CATCH TRIAL",

abstract = "Objective: To determine the feasibility and short-termefficacy of caregiver-directed constraint-induced movement therapy to improveupper limb function in young children with hemiplegic cerebral palsy. Design: Randomized controlled trial with masked assessment. Setting: Community paediatric therapy services. Subjects: Pre-school children with hemiplegic cerebralpalsy. Interventions: Caregiver-directed constraint-inducedmovement therapy administered using either 24-hour short-arm restraint device(prolonged) or intermittent holding restraint during therapy (manual). Main measures: Primary measures include Assisting Hand Assessment (AHA) at 10 weeks. Secondary measures include adverse events,Quality of Upper Extremity Skills Test and Pediatric Quality of Life Inventory.Feasibility measures include recruitment, retention, data completeness and adherence. Results: About 62/81 (72%) of eligible patients in 16centres were randomized (prolonged restraint n = 30; manual restraint n = 32)with 97% retention at 10 weeks. The mean change at 10 weeks on the AHAlogit-based 0–100 unit was 9.0 (95% confidence interval (CI): 5.7, 12.4;P < 0.001) for prolonged restraint and 5.3 (95% CI: 1.3, 9.4; P = 0.01) formanual restraint with a mean group difference of 3.7 (95% CI: −1.5, 8.8;P = 0.156) (AHA smallest detectable difference = 5 units). No serious relatedadverse events were reported. There were no differences in secondary outcomes.More daily therapy was delivered with prolonged restraint (60 vs 30 minutes;P < 0.001). AHA data were complete at baseline and 10 weeks. Conclusion: Caregiver-directed constraint-induced movement therapy is feasible and associated with improvement in upper limb function at 10 weeks. More therapy was delivered with prolonged than with manual restraint,warranting further testing of this intervention in a longer term trial",

keywords = "Hemiplegic cerebral palsy, constraint induced movement therapy, upper limb rehabilitation, therapy, randomised controlled trial",

author = "Pauline Christmas and Catherine Sackley and Maxwell Feltham and Carole Cummins",

year = "2018",

month = mar,

day = "19",

doi = "10.1177/0269215518763512",

language = "English",

pages = "1--10",

journal = "Clinical Rehabilitation",

issn = "0269-2155",

publisher = "SAGE Publications",

}

A randomised controlled trial to compare two methods of constraint-induced movement therapy to improve functional ability in the affected upper limb in pre-school children with hemiplegic cerebral palsy: CATCH TRIAL. / Christmas, Pauline; Sackley, Catherine; Feltham, Maxwell et al.
In: Clinical Rehabilitation, 19.03.2018, p. 1-10.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A randomised controlled trial to compare two methods of constraint-induced movement therapy to improve functional ability in the affected upper limb in pre-school children with hemiplegic cerebral palsy:

T2 - CATCH TRIAL

AU - Christmas, Pauline

AU - Sackley, Catherine

AU - Feltham, Maxwell

AU - Cummins, Carole

PY - 2018/3/19

Y1 - 2018/3/19

N2 - Objective: To determine the feasibility and short-termefficacy of caregiver-directed constraint-induced movement therapy to improveupper limb function in young children with hemiplegic cerebral palsy. Design: Randomized controlled trial with masked assessment. Setting: Community paediatric therapy services. Subjects: Pre-school children with hemiplegic cerebralpalsy. Interventions: Caregiver-directed constraint-inducedmovement therapy administered using either 24-hour short-arm restraint device(prolonged) or intermittent holding restraint during therapy (manual). Main measures: Primary measures include Assisting Hand Assessment (AHA) at 10 weeks. Secondary measures include adverse events,Quality of Upper Extremity Skills Test and Pediatric Quality of Life Inventory.Feasibility measures include recruitment, retention, data completeness and adherence. Results: About 62/81 (72%) of eligible patients in 16centres were randomized (prolonged restraint n = 30; manual restraint n = 32)with 97% retention at 10 weeks. The mean change at 10 weeks on the AHAlogit-based 0–100 unit was 9.0 (95% confidence interval (CI): 5.7, 12.4;P < 0.001) for prolonged restraint and 5.3 (95% CI: 1.3, 9.4; P = 0.01) formanual restraint with a mean group difference of 3.7 (95% CI: −1.5, 8.8;P = 0.156) (AHA smallest detectable difference = 5 units). No serious relatedadverse events were reported. There were no differences in secondary outcomes.More daily therapy was delivered with prolonged restraint (60 vs 30 minutes;P < 0.001). AHA data were complete at baseline and 10 weeks. Conclusion: Caregiver-directed constraint-induced movement therapy is feasible and associated with improvement in upper limb function at 10 weeks. More therapy was delivered with prolonged than with manual restraint,warranting further testing of this intervention in a longer term trial

AB - Objective: To determine the feasibility and short-termefficacy of caregiver-directed constraint-induced movement therapy to improveupper limb function in young children with hemiplegic cerebral palsy. Design: Randomized controlled trial with masked assessment. Setting: Community paediatric therapy services. Subjects: Pre-school children with hemiplegic cerebralpalsy. Interventions: Caregiver-directed constraint-inducedmovement therapy administered using either 24-hour short-arm restraint device(prolonged) or intermittent holding restraint during therapy (manual). Main measures: Primary measures include Assisting Hand Assessment (AHA) at 10 weeks. Secondary measures include adverse events,Quality of Upper Extremity Skills Test and Pediatric Quality of Life Inventory.Feasibility measures include recruitment, retention, data completeness and adherence. Results: About 62/81 (72%) of eligible patients in 16centres were randomized (prolonged restraint n = 30; manual restraint n = 32)with 97% retention at 10 weeks. The mean change at 10 weeks on the AHAlogit-based 0–100 unit was 9.0 (95% confidence interval (CI): 5.7, 12.4;P < 0.001) for prolonged restraint and 5.3 (95% CI: 1.3, 9.4; P = 0.01) formanual restraint with a mean group difference of 3.7 (95% CI: −1.5, 8.8;P = 0.156) (AHA smallest detectable difference = 5 units). No serious relatedadverse events were reported. There were no differences in secondary outcomes.More daily therapy was delivered with prolonged restraint (60 vs 30 minutes;P < 0.001). AHA data were complete at baseline and 10 weeks. Conclusion: Caregiver-directed constraint-induced movement therapy is feasible and associated with improvement in upper limb function at 10 weeks. More therapy was delivered with prolonged than with manual restraint,warranting further testing of this intervention in a longer term trial

KW - Hemiplegic cerebral palsy

KW - constraint induced movement therapy

KW - upper limb rehabilitation

KW - therapy

KW - randomised controlled trial

U2 - 10.1177/0269215518763512

DO - 10.1177/0269215518763512

M3 - Article

SN - 0269-2155

SP - 1

EP - 10

JO - Clinical Rehabilitation

JF - Clinical Rehabilitation

ER -