A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping
Research output: Contribution to journal › Article › peer-review
Standard
A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping. / Eggebrecht, Adam T; White, Brian R; Ferradal, Silvina L; Chen, Chunxiao; Zhan, Yuxuan; Snyder, Abraham Z; Dehghani, Hamid; Culver, Joseph P.
In: NeuroImage, Vol. 61, No. 4, 16.07.2012, p. 1120-8.Research output: Contribution to journal › Article › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping
AU - Eggebrecht, Adam T
AU - White, Brian R
AU - Ferradal, Silvina L
AU - Chen, Chunxiao
AU - Zhan, Yuxuan
AU - Snyder, Abraham Z
AU - Dehghani, Hamid
AU - Culver, Joseph P
N1 - Copyright © 2012 Elsevier Inc. All rights reserved.
PY - 2012/7/16
Y1 - 2012/7/16
N2 - Functional neuroimaging commands a dominant role in current neuroscience research. However its use in bedside clinical and certain neuro-scientific studies has been limited because the current tools lack the combination of being non-invasive, non-ionizing and portable while maintaining moderate resolution and localization accuracy. Optical neuroimaging satisfies many of these requirements, but, until recent advances in high-density diffuse optical tomography (HD-DOT), has been hampered by limited resolution. While early results of HD-DOT have been promising, a quantitative voxel-wise comparison and validation of HD-DOT against the gold standard of functional magnetic resonance imaging (fMRI) has been lacking. Herein, we provide such an analysis within the visual cortex using matched visual stimulation protocols in a single group of subjects (n=5) during separate HD-DOT and fMRI scanning sessions. To attain the needed voxel-to-voxel co-registration between HD-DOT and fMRI image spaces, we implemented subject-specific head modeling that incorporated MRI anatomy, detailed segmentation, and alignment of source and detector positions. Comparisons of the visual responses found an average localization error between HD-DOT and fMRI of 4.4+/-1mm, significantly less than the average distance between cortical gyri. This specificity demonstrates that HD-DOT has sufficient image quality to be useful as a surrogate for fMRI.
AB - Functional neuroimaging commands a dominant role in current neuroscience research. However its use in bedside clinical and certain neuro-scientific studies has been limited because the current tools lack the combination of being non-invasive, non-ionizing and portable while maintaining moderate resolution and localization accuracy. Optical neuroimaging satisfies many of these requirements, but, until recent advances in high-density diffuse optical tomography (HD-DOT), has been hampered by limited resolution. While early results of HD-DOT have been promising, a quantitative voxel-wise comparison and validation of HD-DOT against the gold standard of functional magnetic resonance imaging (fMRI) has been lacking. Herein, we provide such an analysis within the visual cortex using matched visual stimulation protocols in a single group of subjects (n=5) during separate HD-DOT and fMRI scanning sessions. To attain the needed voxel-to-voxel co-registration between HD-DOT and fMRI image spaces, we implemented subject-specific head modeling that incorporated MRI anatomy, detailed segmentation, and alignment of source and detector positions. Comparisons of the visual responses found an average localization error between HD-DOT and fMRI of 4.4+/-1mm, significantly less than the average distance between cortical gyri. This specificity demonstrates that HD-DOT has sufficient image quality to be useful as a surrogate for fMRI.
KW - Adult
KW - Brain Mapping
KW - Humans
KW - Magnetic Resonance Imaging
KW - Tomography, Optical
KW - Young Adult
U2 - 10.1016/j.neuroimage.2012.01.124
DO - 10.1016/j.neuroimage.2012.01.124
M3 - Article
C2 - 22330315
VL - 61
SP - 1120
EP - 1128
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 4
ER -