A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping

TY - JOUR

T1 - A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping

AU - Eggebrecht, Adam T

AU - White, Brian R

AU - Ferradal, Silvina L

AU - Chen, Chunxiao

AU - Zhan, Yuxuan

AU - Snyder, Abraham Z

AU - Dehghani, Hamid

AU - Culver, Joseph P

N1 - Copyright © 2012 Elsevier Inc. All rights reserved.

PY - 2012/7/16

Y1 - 2012/7/16

N2 - Functional neuroimaging commands a dominant role in current neuroscience research. However its use in bedside clinical and certain neuro-scientific studies has been limited because the current tools lack the combination of being non-invasive, non-ionizing and portable while maintaining moderate resolution and localization accuracy. Optical neuroimaging satisfies many of these requirements, but, until recent advances in high-density diffuse optical tomography (HD-DOT), has been hampered by limited resolution. While early results of HD-DOT have been promising, a quantitative voxel-wise comparison and validation of HD-DOT against the gold standard of functional magnetic resonance imaging (fMRI) has been lacking. Herein, we provide such an analysis within the visual cortex using matched visual stimulation protocols in a single group of subjects (n=5) during separate HD-DOT and fMRI scanning sessions. To attain the needed voxel-to-voxel co-registration between HD-DOT and fMRI image spaces, we implemented subject-specific head modeling that incorporated MRI anatomy, detailed segmentation, and alignment of source and detector positions. Comparisons of the visual responses found an average localization error between HD-DOT and fMRI of 4.4+/-1mm, significantly less than the average distance between cortical gyri. This specificity demonstrates that HD-DOT has sufficient image quality to be useful as a surrogate for fMRI.

AB - Functional neuroimaging commands a dominant role in current neuroscience research. However its use in bedside clinical and certain neuro-scientific studies has been limited because the current tools lack the combination of being non-invasive, non-ionizing and portable while maintaining moderate resolution and localization accuracy. Optical neuroimaging satisfies many of these requirements, but, until recent advances in high-density diffuse optical tomography (HD-DOT), has been hampered by limited resolution. While early results of HD-DOT have been promising, a quantitative voxel-wise comparison and validation of HD-DOT against the gold standard of functional magnetic resonance imaging (fMRI) has been lacking. Herein, we provide such an analysis within the visual cortex using matched visual stimulation protocols in a single group of subjects (n=5) during separate HD-DOT and fMRI scanning sessions. To attain the needed voxel-to-voxel co-registration between HD-DOT and fMRI image spaces, we implemented subject-specific head modeling that incorporated MRI anatomy, detailed segmentation, and alignment of source and detector positions. Comparisons of the visual responses found an average localization error between HD-DOT and fMRI of 4.4+/-1mm, significantly less than the average distance between cortical gyri. This specificity demonstrates that HD-DOT has sufficient image quality to be useful as a surrogate for fMRI.

KW - Adult

KW - Brain Mapping

KW - Humans

KW - Magnetic Resonance Imaging

KW - Tomography, Optical

KW - Young Adult

U2 - 10.1016/j.neuroimage.2012.01.124

DO - 10.1016/j.neuroimage.2012.01.124

M3 - Article

C2 - 22330315

VL - 61

SP - 1120

EP - 1128

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 4

ER -