A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping

Adam T Eggebrecht, Brian R White, Silvina L Ferradal, Chunxiao Chen, Yuxuan Zhan, Abraham Z Snyder, Hamid Dehghani, Joseph P Culver

Research output: Contribution to journalArticlepeer-review

131 Citations (Scopus)

Abstract

Functional neuroimaging commands a dominant role in current neuroscience research. However its use in bedside clinical and certain neuro-scientific studies has been limited because the current tools lack the combination of being non-invasive, non-ionizing and portable while maintaining moderate resolution and localization accuracy. Optical neuroimaging satisfies many of these requirements, but, until recent advances in high-density diffuse optical tomography (HD-DOT), has been hampered by limited resolution. While early results of HD-DOT have been promising, a quantitative voxel-wise comparison and validation of HD-DOT against the gold standard of functional magnetic resonance imaging (fMRI) has been lacking. Herein, we provide such an analysis within the visual cortex using matched visual stimulation protocols in a single group of subjects (n=5) during separate HD-DOT and fMRI scanning sessions. To attain the needed voxel-to-voxel co-registration between HD-DOT and fMRI image spaces, we implemented subject-specific head modeling that incorporated MRI anatomy, detailed segmentation, and alignment of source and detector positions. Comparisons of the visual responses found an average localization error between HD-DOT and fMRI of 4.4+/-1mm, significantly less than the average distance between cortical gyri. This specificity demonstrates that HD-DOT has sufficient image quality to be useful as a surrogate for fMRI.

Original languageEnglish
Pages (from-to)1120-8
Number of pages9
JournalNeuroImage
Volume61
Issue number4
DOIs
Publication statusPublished - 16 Jul 2012

Bibliographical note

Copyright © 2012 Elsevier Inc. All rights reserved.

Keywords

  • Adult
  • Brain Mapping
  • Humans
  • Magnetic Resonance Imaging
  • Tomography, Optical
  • Young Adult

Fingerprint

Dive into the research topics of 'A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping'. Together they form a unique fingerprint.

Cite this