A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

Research output: Contribution to journalArticlepeer-review


  • Y Nakano
  • I Guerrero
  • J R Whittle
  • P W Ingham

Colleges, School and Institutes

External organisations

  • ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK.


The patterning of cells in insect segments requires the exchange of information between cells, which in Drosophila depends on the activity of members of the segment-polarity class of genes. Here we report the molecular characterization of one such gene, patched. We find that patched encodes a large protein with several possible membrane-spanning domains and is expressed in a complex pattern during embryogenesis.


Original languageEnglish
Pages (from-to)508-13
Number of pages6
Issue number6242
Publication statusPublished - 12 Oct 1989


  • Alleles, Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA, Drosophila, Embryo, Nonmammalian, Genes, Membrane Proteins, Molecular Sequence Data, Protein Conformation, Restriction Mapping, Journal Article, Research Support, Non-U.S. Gov't