Abstract
Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is needed for retrograde membrane trafficking from lysosomal and late endosomal compartments and its synthesis is tightly regulated. But how cells regulate PtdIns(3,5)P2 synthesis--for example, in response to hyperosmotic shock--remains unexplained. A paper from the Weisman group gives the most complete picture so far of a multiprotein complex that controls PtdIns(3,5)P2 synthesis and explains how a VAC14 mutation functionally impairs the scaffold protein at the heart of the complex and causes a neurodegenerative condition in mice.
Original language | English |
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Pages (from-to) | 86-7 |
Number of pages | 2 |
Journal | The EMBO journal |
Volume | 28 |
Issue number | 2 |
DOIs |
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Publication status | Published - 21 Jan 2009 |