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Abstract
This is a phase II clinical trial investigating the safety and efficacy of intravenous vaccination with mature autologous dendritic cells (DCs) pulsed ex vivo with a liver tumor cell line lysate (HepG2) in patients with advanced hepatocellular carcinoma (HCC). HCC is an attractive target for immunotherapy as evidenced by an active recruitment of tumor-infiltrating lymphocytes that are capable of lysing autologous tumor cells in ex vivo studies. DCs are the most potent antigen-presenting cells, with the capacity to take up, process, and present tumor antigens to T cells and stimulate an immune response, thus providing a rational platform for vaccine development. Thirty-five patients with advanced HCC and not suitable for radical or loco-regional therapies received a maximum of six DC vaccinations each at 3-week intervals. In total, 134 DC infusions were administered with no significant toxicity and no evidence of autoimmunity. Twenty-five patients who received at least three vaccine infusions were assessed clinically for response. The radiologically determined disease control rate (combined partial response and stable disease >= 3 months) was 28%. In 17 patients the baseline serum alpha-fetoprotein (AFP) was >= 1,000 ng/ml; in four of these patients, it fell to
Original language | English |
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Pages (from-to) | 124-132 |
Number of pages | 9 |
Journal | Hepatology |
Volume | 49 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2009 |
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Dive into the research topics of 'A Phase II Study of Adoptive Immunotherapy Using Dendritic Cells Pulsed with Tumor Lysate in Patients with Hepatocellular Carcinoma'. Together they form a unique fingerprint.Projects
- 1 Finished
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Lymphocyte Ligands for the Endothelial Adhesion Molecule Vascular Adhesion Protein-1
Adams, D. & Wakelam, M.
15/01/04 → 31/03/07
Project: Research Councils