A pair-wise relationships model of hematopoietic fate determination

Research output: Chapter in Book/Report/Conference proceedingChapter

Authors

External organisations

  • University of Basel
  • National University of Ireland Galway

Abstract

For more than twenty years, most models of hematopoiesis have been branching trees that include an early lymphoid/myeloid dichotomy. However, the field now appears to be turning away from such deterministic viewpoints. Events such as the recent demise of the common lymphoid progenitor have spawned a plethora of new developmental trees, but without leading to consensus on any single depiction. Instead of precise trees, we offer a model that simply considers a series of pair-wise developmental relationships between the various hematopoietic lineages, with decisions also influenced by signals from cell-surface receptors (for interleukins, colony-stimulating factors, etc.). The evidence for pair-wise relationships comes from: (i) the sets of fates available to various cell lines and oligopotent progenitors; and (ii) the patterns of regulation of various hematopoietic fates by complex sets of transcription factors. Each transcription factor seems, by promoting or suppressing lineage options on either side of fate boundaries, to contribute to determining the boundaries of sets of contiguous and related fates and to drive final choices between adjacent fates.

Details

Original languageEnglish
Title of host publicationCell Determination during Hematopoiesis
Publication statusPublished - 1 Dec 2009