A P300-based cognitive assessment battery

Research output: Contribution to journalArticlepeer-review


  • Aaron Kirschner
  • Damian Cruse
  • Srivas Chennu
  • Adrian M Owen
  • Adam Hampshire

Colleges, School and Institutes


BACKGROUND: It is well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are capable of higher cognitive processes.

METHODS: Here, we develop a series of EEG paradigms that probe several core aspects of cognition at the bedside without the need for motor responses and explore the sensitivity of this approach in a group of healthy controls.

RESULTS: Using analysis of ERPs alone, this method can determine with high reliability whether individual participants are able to attend a stimulus stream, maintain items in working memory, or solve complex grammatical reasoning problems.

CONCLUSION: We suggest that this approach could form the basis of a brain-based battery for assessing higher cognition in patients with severe motor impairments or disorders of consciousness.


Original languageEnglish
Pages (from-to)e00336
JournalBrain and Behavior
Issue number6
Publication statusPublished - Jun 2015


  • Cognition, Electroencephalography, Evoked Potentials, Female, Healthy Volunteers, Humans, Male, Memory, Short-Term, Persistent Vegetative State, Point-of-Care Testing, Reproducibility of Results, Sensitivity and Specificity, Synaptic Transmission, Task Performance and Analysis, Young Adult