A novel protecting group methodology for syntheses using nitroxides

Research output: Contribution to journalArticle

Authors

  • Benjamin A. Chalmers
  • Jason C. Morris
  • Kathryn E. Fairfull-Smith
  • Richard Grainger
  • Steven E. Bottle

Colleges, School and Institutes

External organisations

  • Queensland University of Technology QUT

Abstract

The methoxyamine group represents an ideal protecting group for the nitroxide moiety. It can be easily and selectively introduced in high yield (typically >90%) to a range of functionalised nitroxides using FeSO 4·7H2O and H2O2 in DMSO. Its removal is readily achieved under mild conditions in high yield (70-90%) using mCPBA in a Cope-type elimination process.

Details

Original languageEnglish
Pages (from-to)10382-10384
Number of pages3
JournalChemical Communications
Volume49
Issue number88
Publication statusPublished - 14 Nov 2013