A new variant of mcr-3 in an extensively drug-resistant Escherichia coli clinical isolate carrying mcr-1 and blaNDM-5

Lu Liu; Yu Feng; Xiaoxia Zhang; Alan McNally; Zhiyong Zong

doi:10.1128/AAC.01757-17

A new variant of mcr-3 in an extensively drug-resistant Escherichia coli clinical isolate carrying mcr-1 and blaNDM-5

Lu Liu, Yu Feng, Xiaoxia Zhang, Alan McNally, Zhiyong Zong

Microbiology and Infection

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly-identified mcr-3, and a carbapenemase gene blaNDM-5mcr-3 is a new variant (mcr-3.5) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by an TnAs3-like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that mcr-3 may have widely spread.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	12
Early online date	2 Oct 2017
DOIs	https://doi.org/10.1128/AAC.01757-17
Publication status	Published - 1 Dec 2017

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title = "A new variant of mcr-3 in an extensively drug-resistant Escherichia coli clinical isolate carrying mcr-1 and blaNDM-5",

abstract = "A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly-identified mcr-3, and a carbapenemase gene blaNDM-5mcr-3 is a new variant (mcr-3.5) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by an TnAs3-like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that mcr-3 may have widely spread.",

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AU - McNally, Alan

AU - Zong, Zhiyong

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AB - A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly-identified mcr-3, and a carbapenemase gene blaNDM-5mcr-3 is a new variant (mcr-3.5) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by an TnAs3-like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that mcr-3 may have widely spread.

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A new variant of mcr-3 in an extensively drug-resistant Escherichia coli clinical isolate carrying mcr-1 and blaNDM-5

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