A new class of bioactive glasses: calcium-magnesium sulfophosphates

Research output: Contribution to journalArticlepeer-review

Authors

  • Robert Meszaros
  • Dominik Orzol
  • Michel Woy
  • Yu Ling Zhang
  • Kerstin Tiedemann
  • Lothar Wondraczek
  • Svetlana Komarova
  • Jake E. Barralet

Colleges, School and Institutes

External organisations

  • Friedrich-Alexander-Universität Erlangen-Nürnberg
  • McGill University
  • Institut für Geowissenschaften
  • Montreal General Hospital

Abstract

Low-melting ionic sulfophosphate glasses from the system P 2O5-SO4-MO-Na2O (M=Zn2+, Ca2+ or Mg2+) have been previously shown by us to allow tuneable aqueous dissolution and also enable processing temperatures well below 400°C. Sulfate ions are extremely safe for use in the body as decades of use of calcium sulfate bone grafts testifies and there is no known limit on their adult oral toxicity. This glass system therefore offers great potential for use as biomaterials, especially in organic-inorganic hybrid systems such as glass-polymer composites for tissue engineering or drug encapsulation and delivery applications. A compositional region was identified where stable sulfophosphates of the type P2O5-SO4-(Ca, Mg, Zn)O-Na2O can be fabricated. For these glasses, the viscosity-temperature-dependence, glass transformation temperatures (T g) and the onset of crystallization were evaluated as the primary processing parameters. As a first step in exploring their potential as a biomaterial, in this study we examine the bioactivity of several compositions of these glasses using fibroblast, monocyte, and osteoclast cell culture models to determine cellular responses in terms of attachment, proliferation, differentiation, and toxicity.

Details

Original languageEnglish
Pages (from-to)2842-2848
Number of pages7
JournalJournal of Biomedical Materials Research Part A
Volume102
Issue number8
Early online date25 Sep 2013
Publication statusPublished - Aug 2014

Keywords

  • biocompatibility, bioglass, cell response, degradable glass, sulfophosphate glass