A new approach to high-shear mixer granulation using positron emission particle tracking

Y Saito; X Fan; Andrew Ingram; JPK Seville

doi:10.1016/j.ces.2010.09.028

A new approach to high-shear mixer granulation using positron emission particle tracking

Y Saito, X Fan, Andrew Ingram, JPK Seville

Chemical Engineering

Research output: Contribution to journal › Article

15 Citations (Scopus)

Abstract

Positron emission particle tracking (PEPT) can provide quantitative information on particle motion in a mixer. For the first time, the present study clarifies the flow patterns of particles and granules during the process in which granules are formed in high-shear mixer granulation in three dimensions using PEPT. A number of different regions with size-dependent flows account for the variations in frequency and velocity of collisions between differently sized granules in the kernel when segregation occurs in the granulator. These findings offer a better understanding of the product properties and process attributes of high-shear mixer granulation, which will be of direct benefit as pharmaceutical and other products become more complex. (c) 2010 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	563-569
Number of pages	7
Journal	Chemical Engineering Science
Volume	66
Issue number	4
DOIs	https://doi.org/10.1016/j.ces.2010.09.028
Publication status	Published - 1 Feb 2011

Keywords

Positron emission particle tracking
Granulation
Particle processing
Visualization
Powder technology
High-shear mixer

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10.1016/j.ces.2010.09.028

Platform Grant for the University of Birmingham Positron Imaging Centre
Parker, D., Bakalis, S., Barigou, M., Seville, J. & Fryer, P.
Engineering & Physical Science Research Council
1/01/09 → 31/12/13
Project: Research Councils

Cite this

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title = "A new approach to high-shear mixer granulation using positron emission particle tracking",

abstract = "Positron emission particle tracking (PEPT) can provide quantitative information on particle motion in a mixer. For the first time, the present study clarifies the flow patterns of particles and granules during the process in which granules are formed in high-shear mixer granulation in three dimensions using PEPT. A number of different regions with size-dependent flows account for the variations in frequency and velocity of collisions between differently sized granules in the kernel when segregation occurs in the granulator. These findings offer a better understanding of the product properties and process attributes of high-shear mixer granulation, which will be of direct benefit as pharmaceutical and other products become more complex. (c) 2010 Elsevier Ltd. All rights reserved.",

keywords = "Positron emission particle tracking, Granulation, Particle processing, Visualization, Powder technology, High-shear mixer",

author = "Y Saito and X Fan and Andrew Ingram and JPK Seville",

year = "2011",

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doi = "10.1016/j.ces.2010.09.028",

language = "English",

volume = "66",

pages = "563--569",

journal = "Chemical Engineering Science",

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T1 - A new approach to high-shear mixer granulation using positron emission particle tracking

AU - Saito, Y

AU - Fan, X

AU - Ingram, Andrew

AU - Seville, JPK

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Positron emission particle tracking (PEPT) can provide quantitative information on particle motion in a mixer. For the first time, the present study clarifies the flow patterns of particles and granules during the process in which granules are formed in high-shear mixer granulation in three dimensions using PEPT. A number of different regions with size-dependent flows account for the variations in frequency and velocity of collisions between differently sized granules in the kernel when segregation occurs in the granulator. These findings offer a better understanding of the product properties and process attributes of high-shear mixer granulation, which will be of direct benefit as pharmaceutical and other products become more complex. (c) 2010 Elsevier Ltd. All rights reserved.

AB - Positron emission particle tracking (PEPT) can provide quantitative information on particle motion in a mixer. For the first time, the present study clarifies the flow patterns of particles and granules during the process in which granules are formed in high-shear mixer granulation in three dimensions using PEPT. A number of different regions with size-dependent flows account for the variations in frequency and velocity of collisions between differently sized granules in the kernel when segregation occurs in the granulator. These findings offer a better understanding of the product properties and process attributes of high-shear mixer granulation, which will be of direct benefit as pharmaceutical and other products become more complex. (c) 2010 Elsevier Ltd. All rights reserved.

KW - Positron emission particle tracking

KW - Granulation

KW - Particle processing

KW - Visualization

KW - Powder technology

KW - High-shear mixer

U2 - 10.1016/j.ces.2010.09.028

DO - 10.1016/j.ces.2010.09.028

M3 - Article

SN - 1873-4405

VL - 66

SP - 563

EP - 569

JO - Chemical Engineering Science

JF - Chemical Engineering Science

IS - 4

ER -

A new approach to high-shear mixer granulation using positron emission particle tracking

Abstract

Keywords

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Platform Grant for the University of Birmingham Positron Imaging Centre

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