A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans

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A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans. / Miyakawa, Hitoshi; Toyota, Kenji; Hirakawa, Ikumi; Ogino, Yukiko; Miyagawa, Shinichi; Oda, Shigeto; Tatarazako, Norihisa; Miura, Toru; Colbourne, John K; Iguchi, Taisen.

In: Nature Communications, Vol. 4, 2013, p. 1856.

Research output: Contribution to journalArticlepeer-review

Harvard

Miyakawa, H, Toyota, K, Hirakawa, I, Ogino, Y, Miyagawa, S, Oda, S, Tatarazako, N, Miura, T, Colbourne, JK & Iguchi, T 2013, 'A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans', Nature Communications, vol. 4, pp. 1856. https://doi.org/10.1038/ncomms2868

APA

Miyakawa, H., Toyota, K., Hirakawa, I., Ogino, Y., Miyagawa, S., Oda, S., Tatarazako, N., Miura, T., Colbourne, J. K., & Iguchi, T. (2013). A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans. Nature Communications, 4, 1856. https://doi.org/10.1038/ncomms2868

Vancouver

Author

Miyakawa, Hitoshi ; Toyota, Kenji ; Hirakawa, Ikumi ; Ogino, Yukiko ; Miyagawa, Shinichi ; Oda, Shigeto ; Tatarazako, Norihisa ; Miura, Toru ; Colbourne, John K ; Iguchi, Taisen. / A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans. In: Nature Communications. 2013 ; Vol. 4. pp. 1856.

Bibtex

@article{fcbcbd9fdfb74958a4d0909c7b06cb30,
title = "A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans",
abstract = "Juvenile hormone is an essential regulator of major developmental and life history events in arthropods. Most of the insects use juvenile hormone III as the innate juvenile hormone ligand. By contrast, crustaceans use methyl farnesoate. Despite this difference that is tied to their deep evolutionary divergence, the process of this ligand transition is unknown. Here we show that a single amino-acid substitution in the receptor Methoprene-tolerant has an important role during evolution of the arthropod juvenile hormone pathway. Microcrustacea Daphnia pulex and D. magna share a juvenile hormone signal transduction pathway with insects, involving Methoprene-tolerant and steroid receptor coactivator proteins that form a heterodimer in response to various juvenoids. Juvenile hormone-binding pockets of the orthologous genes differ by only two amino acids, yet a single substitution within Daphnia Met enhances the receptor's responsiveness to juvenile hormone III. These results indicate that this mutation within an ancestral insect lineage contributed to the evolution of a juvenile hormone III receptor system.",
author = "Hitoshi Miyakawa and Kenji Toyota and Ikumi Hirakawa and Yukiko Ogino and Shinichi Miyagawa and Shigeto Oda and Norihisa Tatarazako and Toru Miura and Colbourne, {John K} and Taisen Iguchi",
year = "2013",
doi = "10.1038/ncomms2868",
language = "English",
volume = "4",
pages = "1856",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans

AU - Miyakawa, Hitoshi

AU - Toyota, Kenji

AU - Hirakawa, Ikumi

AU - Ogino, Yukiko

AU - Miyagawa, Shinichi

AU - Oda, Shigeto

AU - Tatarazako, Norihisa

AU - Miura, Toru

AU - Colbourne, John K

AU - Iguchi, Taisen

PY - 2013

Y1 - 2013

N2 - Juvenile hormone is an essential regulator of major developmental and life history events in arthropods. Most of the insects use juvenile hormone III as the innate juvenile hormone ligand. By contrast, crustaceans use methyl farnesoate. Despite this difference that is tied to their deep evolutionary divergence, the process of this ligand transition is unknown. Here we show that a single amino-acid substitution in the receptor Methoprene-tolerant has an important role during evolution of the arthropod juvenile hormone pathway. Microcrustacea Daphnia pulex and D. magna share a juvenile hormone signal transduction pathway with insects, involving Methoprene-tolerant and steroid receptor coactivator proteins that form a heterodimer in response to various juvenoids. Juvenile hormone-binding pockets of the orthologous genes differ by only two amino acids, yet a single substitution within Daphnia Met enhances the receptor's responsiveness to juvenile hormone III. These results indicate that this mutation within an ancestral insect lineage contributed to the evolution of a juvenile hormone III receptor system.

AB - Juvenile hormone is an essential regulator of major developmental and life history events in arthropods. Most of the insects use juvenile hormone III as the innate juvenile hormone ligand. By contrast, crustaceans use methyl farnesoate. Despite this difference that is tied to their deep evolutionary divergence, the process of this ligand transition is unknown. Here we show that a single amino-acid substitution in the receptor Methoprene-tolerant has an important role during evolution of the arthropod juvenile hormone pathway. Microcrustacea Daphnia pulex and D. magna share a juvenile hormone signal transduction pathway with insects, involving Methoprene-tolerant and steroid receptor coactivator proteins that form a heterodimer in response to various juvenoids. Juvenile hormone-binding pockets of the orthologous genes differ by only two amino acids, yet a single substitution within Daphnia Met enhances the receptor's responsiveness to juvenile hormone III. These results indicate that this mutation within an ancestral insect lineage contributed to the evolution of a juvenile hormone III receptor system.

U2 - 10.1038/ncomms2868

DO - 10.1038/ncomms2868

M3 - Article

C2 - 23673641

VL - 4

SP - 1856

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -