A Mitsunobu reaction to functionalized cyclic and bicyclic N-arylamines
Research output: Contribution to journal › Article › peer-review
- Manchester Metropolitan University
- The Institute of Cancer Research
The scope of an unexpected Mitsunobu cyclisation to prepare N-arylated Fsp3-enriched azacycles was investigated. In the current study, we have identified whether a pKa-dependent Mitsunobu cyclodehydration or a pKa-independent Mitsunobu intramolecular reaction was in operation. A Mitsunobu reaction, creating a leaving group, followed by intramolecular nucleophilic displacement was determined to be the dominant pathway.
|Early online date||6 Dec 2017|
|Publication status||Published - 17 Jan 2018|
- mitsunobu , cyclodehydration , nucleophilic aromatic substitution , intramolecular , cyclisation