A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe

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A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe. / Donoghue, Helen D; Michael Taylor, G; Marcsik, Antónia; Molnár, Erika; Pálfi, Gyorgy; Pap, Ildikó; Teschler-Nicola, Maria; Pinhasi, Ron; Erdal, Yilmaz S; Velemínsky, Petr; Likovsky, Jakub; Belcastro, Maria Giovanna; Mariotti, Valentina; Riga, Alessandro; Rubini, Mauro; Zaio, Paola; Besra, Gurdyal S; Lee, Oona Y-C; Wu, Houdini H T; Minnikin, David E; Bull, Ian D; O'Grady, Justin; Spigelman, Mark.

In: Infection, Genetics and Evolution, Vol. 31, 04.2015, p. 250-6.

Research output: Contribution to journalArticle

Harvard

Donoghue, HD, Michael Taylor, G, Marcsik, A, Molnár, E, Pálfi, G, Pap, I, Teschler-Nicola, M, Pinhasi, R, Erdal, YS, Velemínsky, P, Likovsky, J, Belcastro, MG, Mariotti, V, Riga, A, Rubini, M, Zaio, P, Besra, GS, Lee, OY-C, Wu, HHT, Minnikin, DE, Bull, ID, O'Grady, J & Spigelman, M 2015, 'A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe', Infection, Genetics and Evolution, vol. 31, pp. 250-6. https://doi.org/10.1016/j.meegid.2015.02.001

APA

Donoghue, H. D., Michael Taylor, G., Marcsik, A., Molnár, E., Pálfi, G., Pap, I., Teschler-Nicola, M., Pinhasi, R., Erdal, Y. S., Velemínsky, P., Likovsky, J., Belcastro, M. G., Mariotti, V., Riga, A., Rubini, M., Zaio, P., Besra, G. S., Lee, O. Y-C., Wu, H. H. T., ... Spigelman, M. (2015). A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe. Infection, Genetics and Evolution, 31, 250-6. https://doi.org/10.1016/j.meegid.2015.02.001

Vancouver

Author

Donoghue, Helen D ; Michael Taylor, G ; Marcsik, Antónia ; Molnár, Erika ; Pálfi, Gyorgy ; Pap, Ildikó ; Teschler-Nicola, Maria ; Pinhasi, Ron ; Erdal, Yilmaz S ; Velemínsky, Petr ; Likovsky, Jakub ; Belcastro, Maria Giovanna ; Mariotti, Valentina ; Riga, Alessandro ; Rubini, Mauro ; Zaio, Paola ; Besra, Gurdyal S ; Lee, Oona Y-C ; Wu, Houdini H T ; Minnikin, David E ; Bull, Ian D ; O'Grady, Justin ; Spigelman, Mark. / A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe. In: Infection, Genetics and Evolution. 2015 ; Vol. 31. pp. 250-6.

Bibtex

@article{d6dce7e7b2374a3fbc709b04a4de7607,
title = "A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe",
abstract = "Leprosy was rare in Europe during the Roman period, yet its prevalence increased dramatically in medieval times. We examined human remains, with paleopathological lesions indicative of leprosy, dated to the 6th-11th century AD, from Central and Eastern Europe and Byzantine Anatolia. Analysis of ancient DNA and bacterial cell wall lipid biomarkers revealed Mycobacterium leprae in skeletal remains from 6th-8th century Northern Italy, 7th-11th century Hungary, 8th-9th century Austria, the Slavic Greater Moravian Empire of the 9th-10th century and 8th-10th century Byzantine samples from Northern Anatolia. These data were analyzed alongside findings published by others. M. leprae is an obligate human pathogen that has undergone an evolutionary bottleneck followed by clonal expansion. Therefore M. leprae genotypes and sub-genotypes give information about the human populations they have infected and their migration. Although data are limited, genotyping demonstrates that historical M. leprae from Byzantine Anatolia, Eastern and Central Europe resembles modern strains in Asia Minor rather than the recently characterized historical strains from North West Europe. The westward migration of peoples from Central Asia in the first millennium may have introduced different M. leprae strains into medieval Europe and certainly would have facilitated the spread of any existing leprosy. The subsequent decline of M. leprae in Europe may be due to increased host resistance. However, molecular evidence of historical leprosy and tuberculosis co-infections suggests that death from tuberculosis in leprosy patients was also a factor.",
author = "Donoghue, {Helen D} and {Michael Taylor}, G and Ant{\'o}nia Marcsik and Erika Moln{\'a}r and Gyorgy P{\'a}lfi and Ildik{\'o} Pap and Maria Teschler-Nicola and Ron Pinhasi and Erdal, {Yilmaz S} and Petr Velem{\'i}nsky and Jakub Likovsky and Belcastro, {Maria Giovanna} and Valentina Mariotti and Alessandro Riga and Mauro Rubini and Paola Zaio and Besra, {Gurdyal S} and Lee, {Oona Y-C} and Wu, {Houdini H T} and Minnikin, {David E} and Bull, {Ian D} and Justin O'Grady and Mark Spigelman",
note = "Copyright {\textcopyright} 2015. Published by Elsevier B.V.",
year = "2015",
month = apr,
doi = "10.1016/j.meegid.2015.02.001",
language = "English",
volume = "31",
pages = "250--6",
journal = "Infection, Genetics and Evolution",
issn = "1567-1348",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe

AU - Donoghue, Helen D

AU - Michael Taylor, G

AU - Marcsik, Antónia

AU - Molnár, Erika

AU - Pálfi, Gyorgy

AU - Pap, Ildikó

AU - Teschler-Nicola, Maria

AU - Pinhasi, Ron

AU - Erdal, Yilmaz S

AU - Velemínsky, Petr

AU - Likovsky, Jakub

AU - Belcastro, Maria Giovanna

AU - Mariotti, Valentina

AU - Riga, Alessandro

AU - Rubini, Mauro

AU - Zaio, Paola

AU - Besra, Gurdyal S

AU - Lee, Oona Y-C

AU - Wu, Houdini H T

AU - Minnikin, David E

AU - Bull, Ian D

AU - O'Grady, Justin

AU - Spigelman, Mark

N1 - Copyright © 2015. Published by Elsevier B.V.

PY - 2015/4

Y1 - 2015/4

N2 - Leprosy was rare in Europe during the Roman period, yet its prevalence increased dramatically in medieval times. We examined human remains, with paleopathological lesions indicative of leprosy, dated to the 6th-11th century AD, from Central and Eastern Europe and Byzantine Anatolia. Analysis of ancient DNA and bacterial cell wall lipid biomarkers revealed Mycobacterium leprae in skeletal remains from 6th-8th century Northern Italy, 7th-11th century Hungary, 8th-9th century Austria, the Slavic Greater Moravian Empire of the 9th-10th century and 8th-10th century Byzantine samples from Northern Anatolia. These data were analyzed alongside findings published by others. M. leprae is an obligate human pathogen that has undergone an evolutionary bottleneck followed by clonal expansion. Therefore M. leprae genotypes and sub-genotypes give information about the human populations they have infected and their migration. Although data are limited, genotyping demonstrates that historical M. leprae from Byzantine Anatolia, Eastern and Central Europe resembles modern strains in Asia Minor rather than the recently characterized historical strains from North West Europe. The westward migration of peoples from Central Asia in the first millennium may have introduced different M. leprae strains into medieval Europe and certainly would have facilitated the spread of any existing leprosy. The subsequent decline of M. leprae in Europe may be due to increased host resistance. However, molecular evidence of historical leprosy and tuberculosis co-infections suggests that death from tuberculosis in leprosy patients was also a factor.

AB - Leprosy was rare in Europe during the Roman period, yet its prevalence increased dramatically in medieval times. We examined human remains, with paleopathological lesions indicative of leprosy, dated to the 6th-11th century AD, from Central and Eastern Europe and Byzantine Anatolia. Analysis of ancient DNA and bacterial cell wall lipid biomarkers revealed Mycobacterium leprae in skeletal remains from 6th-8th century Northern Italy, 7th-11th century Hungary, 8th-9th century Austria, the Slavic Greater Moravian Empire of the 9th-10th century and 8th-10th century Byzantine samples from Northern Anatolia. These data were analyzed alongside findings published by others. M. leprae is an obligate human pathogen that has undergone an evolutionary bottleneck followed by clonal expansion. Therefore M. leprae genotypes and sub-genotypes give information about the human populations they have infected and their migration. Although data are limited, genotyping demonstrates that historical M. leprae from Byzantine Anatolia, Eastern and Central Europe resembles modern strains in Asia Minor rather than the recently characterized historical strains from North West Europe. The westward migration of peoples from Central Asia in the first millennium may have introduced different M. leprae strains into medieval Europe and certainly would have facilitated the spread of any existing leprosy. The subsequent decline of M. leprae in Europe may be due to increased host resistance. However, molecular evidence of historical leprosy and tuberculosis co-infections suggests that death from tuberculosis in leprosy patients was also a factor.

U2 - 10.1016/j.meegid.2015.02.001

DO - 10.1016/j.meegid.2015.02.001

M3 - Article

C2 - 25680828

VL - 31

SP - 250

EP - 256

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

SN - 1567-1348

ER -