A longitudinal follow-up study of affect in children and adults with Cornelia de Lange syndrome

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

Studies of individuals with Cornelia de Lange syndrome (CdLS) have described changes in mood and behavior with age, although no empirical or longitudinal studies have been conducted. Caregivers of individuals with CdLS (N  =  67), cri du chat syndrome (CdCS; N  =  42), and Fragile X syndrome (FXS; N  =  142) completed the Mood, Interest and Pleasure Questionnaire (MIPQ) at Time 1 and 2 years later (Time 2). Scores on the MIPQ were significantly lower in the CdLS group compared with the CdCS and FXS groups at Time 1 and Time 2. Lower MIPQ scores were characteristic of older adolescents (> 15 years) and adults with CdLS. However, there were no significant differences in MIPQ scores between Time 1 and Time 2. Age and insistence on sameness predicted MIPQ scores in CdLS.

Bibliographic note

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Details

Original languageEnglish
Pages (from-to)235-252
Number of pages18
JournalAmerican Journal on Intellectual and Developmental Disabilities
Volume119
Issue number3
Publication statusPublished - May 2014

Keywords

  • Affect, Behavioral phenotypes, Cornelia de Lange syndrome, Follow-up, Longitudinal, adolescent, adult, affect, age, article, behavioral phenotypes, cat cry syndrome, child, comparative study, de Lange syndrome, female, follow up, follow-up, fragile X syndrome, human, longitudinal, male, middle aged, pathophysiology, phenotype, physiology, predictive value, preschool child, young adult, Adolescent, Adult, Age Factors, Child, Child, Preschool, Cri-du-Chat Syndrome, De Lange Syndrome, Female, Follow-Up Studies, Fragile X Syndrome, Humans, Male, Middle Aged, Phenotype, Predictive Value of Tests, Young Adult