A kinetic analysis methodology to elucidate the roles of metal, support and solvent for the hydrogenation of 4-phenyl-2-butanone over Pt/TiO2

Research output: Contribution to journalArticlepeer-review


  • Sam Wilkinson
  • Iain McManus
  • Helen Daly
  • Jillian Thompson
  • Chris Hardacre
  • Nazita Sedaie Bonab
  • J ten Dam
  • C D Agostino
  • James Mc Gregor
  • LF Gladden
  • E. Hugh Stitt

Colleges, School and Institutes


The rate and, more importantly, selectivity (ketone vs aromatic ring) of the hydrogenation of 4-phenyl-2-butanone over a Pt/TiO2 catalyst have been shown to vary with solvent. In this study, a fundamental kinetic model for this multi-phase reaction has been developed incorporating statistical analysis methods to strengthen the foundations of mechanistically sound kinetic models.

A 2-site model was determined to be most appropriate, describing aromatic hydrogenation (postulated to be over a platinum site) and ketone hydrogenation (postulated to be at the platinum–titania interface). Solvent choice has little impact on the ketone hydrogenation rate constant but strongly impacts aromatic hydrogenation due to solvent-catalyst interaction. Reaction selectivity is also correlated to a fitted product adsorption constant parameter. The kinetic analysis method shown has demonstrated the role of solvents in influencing reactant adsorption and reaction selectivity.


Original languageEnglish
Pages (from-to)362-73
Number of pages12
JournalJournal of Catalysis
Early online date22 Aug 2015
Publication statusPublished - Oct 2015


  • Selective hydrogenation, Solvent effect, Kinetic modelling, Aromatic ketone, Pt, Titania