A hierarchy of event-related potential markers of auditory processing in disorders of consciousness

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A hierarchy of event-related potential markers of auditory processing in disorders of consciousness. / Beukema, Steve; Gonzalez-lara, Laura E.; Finoia, Paola; Kamau, Evelyn; Allanson, Judith; Chennu, Srivas; Gibson, Raechelle M.; Pickard, John D.; Owen, Adrian M.; Cruse, Damian.

In: NeuroImage: Clinical, Vol. 12, 2016, p. 359-371.

Research output: Contribution to journalArticle

Harvard

Beukema, S, Gonzalez-lara, LE, Finoia, P, Kamau, E, Allanson, J, Chennu, S, Gibson, RM, Pickard, JD, Owen, AM & Cruse, D 2016, 'A hierarchy of event-related potential markers of auditory processing in disorders of consciousness', NeuroImage: Clinical, vol. 12, pp. 359-371. https://doi.org/10.1016/j.nicl.2016.08.003

APA

Beukema, S., Gonzalez-lara, L. E., Finoia, P., Kamau, E., Allanson, J., Chennu, S., Gibson, R. M., Pickard, J. D., Owen, A. M., & Cruse, D. (2016). A hierarchy of event-related potential markers of auditory processing in disorders of consciousness. NeuroImage: Clinical, 12, 359-371. https://doi.org/10.1016/j.nicl.2016.08.003

Vancouver

Author

Beukema, Steve ; Gonzalez-lara, Laura E. ; Finoia, Paola ; Kamau, Evelyn ; Allanson, Judith ; Chennu, Srivas ; Gibson, Raechelle M. ; Pickard, John D. ; Owen, Adrian M. ; Cruse, Damian. / A hierarchy of event-related potential markers of auditory processing in disorders of consciousness. In: NeuroImage: Clinical. 2016 ; Vol. 12. pp. 359-371.

Bibtex

@article{07b11f8fb30f4cbca8e408fe8405d921,
title = "A hierarchy of event-related potential markers of auditory processing in disorders of consciousness",
abstract = "Functional neuroimaging of covert perceptual and cognitive processes can inform the diagnoses and prognoses of patients with disorders of consciousness, such as the vegetative and minimally conscious states (VS;MCS). Here we report an event-related potential (ERP) paradigm for detecting a hierarchy of auditory processes in a group of healthy individuals and patients with disorders of consciousness. Simple cortical responses to sounds were observed in all 16 patients; 7/16 (44%) patients exhibited markers of the differential processing of speech and noise; and 1 patient produced evidence of the semantic processing of speech (i.e. the N400 effect). In several patients, the level of auditory processing that was evident from ERPs was higher than the abilities that were evident from behavioural assessment, indicating a greater sensitivity of ERPs in some cases. However, there were no differences in auditory processing between VS and MCS patient groups, indicating a lack of diagnostic specificity for this paradigm. Reliably detecting semantic processing by means of the N400 effect in passively listening single-subjects is a challenge. Multiple assessment methods are needed in order to fully characterise the abilities of patients with disorders of consciousness.",
keywords = "Disorders of consciousness, N400, Auditory processing, Vegetative state, Minimally conscious state",
author = "Steve Beukema and Gonzalez-lara, {Laura E.} and Paola Finoia and Evelyn Kamau and Judith Allanson and Srivas Chennu and Gibson, {Raechelle M.} and Pickard, {John D.} and Owen, {Adrian M.} and Damian Cruse",
year = "2016",
doi = "10.1016/j.nicl.2016.08.003",
language = "English",
volume = "12",
pages = "359--371",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - A hierarchy of event-related potential markers of auditory processing in disorders of consciousness

AU - Beukema, Steve

AU - Gonzalez-lara, Laura E.

AU - Finoia, Paola

AU - Kamau, Evelyn

AU - Allanson, Judith

AU - Chennu, Srivas

AU - Gibson, Raechelle M.

AU - Pickard, John D.

AU - Owen, Adrian M.

AU - Cruse, Damian

PY - 2016

Y1 - 2016

N2 - Functional neuroimaging of covert perceptual and cognitive processes can inform the diagnoses and prognoses of patients with disorders of consciousness, such as the vegetative and minimally conscious states (VS;MCS). Here we report an event-related potential (ERP) paradigm for detecting a hierarchy of auditory processes in a group of healthy individuals and patients with disorders of consciousness. Simple cortical responses to sounds were observed in all 16 patients; 7/16 (44%) patients exhibited markers of the differential processing of speech and noise; and 1 patient produced evidence of the semantic processing of speech (i.e. the N400 effect). In several patients, the level of auditory processing that was evident from ERPs was higher than the abilities that were evident from behavioural assessment, indicating a greater sensitivity of ERPs in some cases. However, there were no differences in auditory processing between VS and MCS patient groups, indicating a lack of diagnostic specificity for this paradigm. Reliably detecting semantic processing by means of the N400 effect in passively listening single-subjects is a challenge. Multiple assessment methods are needed in order to fully characterise the abilities of patients with disorders of consciousness.

AB - Functional neuroimaging of covert perceptual and cognitive processes can inform the diagnoses and prognoses of patients with disorders of consciousness, such as the vegetative and minimally conscious states (VS;MCS). Here we report an event-related potential (ERP) paradigm for detecting a hierarchy of auditory processes in a group of healthy individuals and patients with disorders of consciousness. Simple cortical responses to sounds were observed in all 16 patients; 7/16 (44%) patients exhibited markers of the differential processing of speech and noise; and 1 patient produced evidence of the semantic processing of speech (i.e. the N400 effect). In several patients, the level of auditory processing that was evident from ERPs was higher than the abilities that were evident from behavioural assessment, indicating a greater sensitivity of ERPs in some cases. However, there were no differences in auditory processing between VS and MCS patient groups, indicating a lack of diagnostic specificity for this paradigm. Reliably detecting semantic processing by means of the N400 effect in passively listening single-subjects is a challenge. Multiple assessment methods are needed in order to fully characterise the abilities of patients with disorders of consciousness.

KW - Disorders of consciousness

KW - N400

KW - Auditory processing

KW - Vegetative state

KW - Minimally conscious state

U2 - 10.1016/j.nicl.2016.08.003

DO - 10.1016/j.nicl.2016.08.003

M3 - Article

VL - 12

SP - 359

EP - 371

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

SN - 2213-1582

ER -