A Herpes saimiri oncogene causing peripheral T-cell lymphoma in transgenic mice

Research output: Contribution to journalArticlepeer-review

Authors

  • C. Kretschmer
  • B. Biesinger
  • J. Beckers
  • H. Fickenscher
  • T. Kirchner
  • B. Fleckenstein
  • U. Ruther

Colleges, School and Institutes

Abstract

Herpesvirus saimiri is an oncogenic virus causing rapid T-cell lymphomas in New World primates and rabbits. Deletion analysis of one strain of H saimiri has indicated an open reading frame, StpA, necessary for oncongenicity in monkeys. We have investigated the function of StpA in tumor induction by the generation of transgenic mice. Expression of two different constructs caused the development of peripheral lymphomas. The infiltrating cells were of T-cell origin, expressing mainly the CD4 phenotype and restricted sets of V beta chains. Thus, StpA is not only necessary for the oncogenicity of Herpesvirus saimiri, but is also sufficient for the induction of peripheral pleomorphic T-cell lymphomas.

Bibliographic note

M1 - 8 Kretschmer, C Murphy, C Biesinger, B Beckers, J Fickenscher, H Kirchner, T Fleckenstein, B Ruther, U Research Support, Non-U.S. Gov't England Oncogene Oncogene. 1996 Apr 18;12(8):1609-16.

Details

Original languageEnglish
Pages (from-to)1609-1616
Number of pages8
JournalOncogene
Volume12
Publication statusPublished - 1996

Keywords

  • Animals Antigens, CD3 Antigens, CD4 Bacterial Proteins/*genetics Base Sequence Blotting, Northern Cloning, Molecular *DNA-Binding Proteins *Escherichia coli Proteins Gene Expression Herpesvirus 2, Saimiriine/*genetics Immunohistochemistry Lymphocyte Activation Lymphoma, T-Cell/*genetics/*virology Mice Mice, Transgenic/*genetics/*virology *Molecular Chaperones Molecular Sequence Data Oncogene Proteins, Viral/*genetics Phenotype Promoter Regions, Genetic Receptors, Antigen, T-Cell/chemistry/genetics