A gold carbene manifold to prepare fused γ-lactams by oxidative cyclisation of ynamides

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  • School of Chemistry, University of Birmingham , Birmingham, B15 2TT, U.K.


Gold catalysed oxidative cyclisation reactions of ynamides offer great promise in γ-lactam synthesis but are limited by preferential over-oxidation to form α-keto imides. Evaluating the factors that might limit N-cyclisation pathways led to effective gold-catalysed conditions that allow access to different fused γ-lactams on changing the ynamide N-substituent and accommodate previously incompatible substitution patterns. New and efficient methods for the synthesis of functionalised 3-aryl indoles and cyclohepta[c]pyrrol-1-one derivatives are presented. These conditions illustrate the complementarity of gold catalysis to other metals.


Original languageEnglish
Pages (from-to)17215-17219
JournalChemistry: A European Journal
Issue number65
Early online date24 Sep 2018
Publication statusPublished - 22 Nov 2018


  • cyclisation, gold, oxidation, ynamide, γ-lactam

ASJC Scopus subject areas