A gold carbene manifold to prepare fused γ-lactams by oxidative cyclisation of ynamides
Research output: Contribution to journal › Article
Colleges, School and Institutes
- School of Chemistry, University of Birmingham , Birmingham, B15 2TT, U.K.
Gold catalysed oxidative cyclisation reactions of ynamides offer great promise in γ-lactam synthesis but are limited by preferential over-oxidation to form α-keto imides. Evaluating the factors that might limit N-cyclisation pathways led to effective gold-catalysed conditions that allow access to different fused γ-lactams on changing the ynamide N-substituent and accommodate previously incompatible substitution patterns. New and efficient methods for the synthesis of functionalised 3-aryl indoles and cyclohepta[c]pyrrol-1-one derivatives are presented. These conditions illustrate the complementarity of gold catalysis to other metals.
|Journal||Chemistry: A European Journal|
|Early online date||24 Sep 2018|
|Publication status||Published - 22 Nov 2018|