@article{15d2e4b98da64e6aae48ffd4f3323993,
title = "A gold carbene manifold to prepare fused γ-lactams by oxidative cyclisation of ynamides",
abstract = "Gold catalysed oxidative cyclisation reactions of ynamides offer great promise in γ-lactam synthesis but are limited by preferential over-oxidation to form α-keto imides. Evaluating the factors that might limit N-cyclisation pathways led to effective gold-catalysed conditions that allow access to different fused γ-lactams on changing the ynamide N-substituent and accommodate previously incompatible substitution patterns. New and efficient methods for the synthesis of functionalised 3-aryl indoles and cyclohepta[c]pyrrol-1-one derivatives are presented. These conditions illustrate the complementarity of gold catalysis to other metals. ",
keywords = "cyclisation, gold, oxidation, ynamide, γ-lactam",
author = "Paul Davies and Joshua Priest and Fernando Sanchez-Cantalejo",
year = "2018",
month = nov,
day = "22",
doi = "10.1002/chem.201804378",
language = "English",
volume = "24",
pages = "17215--17219",
journal = "Chemistry: A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "65",
}