TY - JOUR
T1 - A Geographically-Restricted but Prevalent Mycobacterium tuberculosis Strain Identified in the West Midlands Region of the UK between 1995 and 2008.
AU - Evans, JT
AU - Serafino Wani, RL
AU - Anderson, L
AU - Gibson, Andrea
AU - Smith, EG
AU - Turner, Alice
AU - Olowokure, Babatunde
AU - Abubakar, I
AU - Mann, Jonathan
AU - Gardiner, S
AU - Kirkby, HM
AU - Sonnenberg, P
AU - Hawkey, Peter
PY - 2011/1/1
Y1 - 2011/1/1
N2 - BACKGROUND
We describe the identification of, and risk factors for, the single most prevalent Mycobacterium tuberculosis strain in the West Midlands region of the UK.
METHODOLOGY/PRINCIPAL FINDINGS
Prospective 15-locus MIRU-VNTR genotyping of all M. tuberculosis isolates in the West Midlands between 2004 and 2008 was undertaken. Two retrospective epidemiological investigations were also undertaken using univariable and multivariable logistic regression analysis. The first study of all TB patients in the West Midlands between 2004 and 2008 identified a single prevalent strain in each of the study years (total 155/3,056 (5%) isolates). This prevalent MIRU-VNTR profile (32333 2432515314 434443183) remained clustered after typing with an additional 9-loci MIRU-VNTR and spoligotyping. The majority of these patients (122/155, 79%) resided in three major cities located within a 40 km radius. From the apparent geographical restriction, we have named this the "Mercian" strain. A multivariate analysis of all TB patients in the West Midlands identified that infection with a Mercian strain was significantly associated with being UK-born (OR = 9.03, 95%CI = 4.56-17.87, p65 years old (OR = 0.25, 95%CI = 0.09-0.67, p
AB - BACKGROUND
We describe the identification of, and risk factors for, the single most prevalent Mycobacterium tuberculosis strain in the West Midlands region of the UK.
METHODOLOGY/PRINCIPAL FINDINGS
Prospective 15-locus MIRU-VNTR genotyping of all M. tuberculosis isolates in the West Midlands between 2004 and 2008 was undertaken. Two retrospective epidemiological investigations were also undertaken using univariable and multivariable logistic regression analysis. The first study of all TB patients in the West Midlands between 2004 and 2008 identified a single prevalent strain in each of the study years (total 155/3,056 (5%) isolates). This prevalent MIRU-VNTR profile (32333 2432515314 434443183) remained clustered after typing with an additional 9-loci MIRU-VNTR and spoligotyping. The majority of these patients (122/155, 79%) resided in three major cities located within a 40 km radius. From the apparent geographical restriction, we have named this the "Mercian" strain. A multivariate analysis of all TB patients in the West Midlands identified that infection with a Mercian strain was significantly associated with being UK-born (OR = 9.03, 95%CI = 4.56-17.87, p65 years old (OR = 0.25, 95%CI = 0.09-0.67, p
U2 - 10.1371/journal.pone.0017930
DO - 10.1371/journal.pone.0017930
M3 - Article
C2 - 21464965
SN - 1932-6203
VL - 6
SP - e17930
JO - PLoS ONE
JF - PLoS ONE
IS - 3
ER -
