A Genome-Wide Linkage and Association Scan Reveals Novel Loci for Hypertension and Blood Pressure Traits

Research output: Contribution to journalArticle


  • Y Guo
  • B Tomlinson
  • T Chu
  • YJ Fang
  • H Gui
  • CS Tang
  • BH Yip
  • SS Cherny
  • YM Hur
  • PC Sham
  • TH Lam

Colleges, School and Institutes


Hypertension is caused by the interaction of environmental and genetic factors. The condition which is very common, with about 18% of the adult Hong Kong Chinese population and over 50% of older individuals affected, is responsible for considerable morbidity and mortality. To identify genes influencing hypertension and blood pressure, we conducted a combined linkage and association study using over 500,000 single nucleotide polymorphisms (SNPs) genotyped in 328 individuals comprising 111 hypertensive probands and their siblings. Using a family-based association test, we found an association with SNPs on chromosome 5q31.1 (rs6596140; P


Original languageEnglish
Pages (from-to)e31489
JournalPLoS ONE
Issue number2
Publication statusPublished - 1 Feb 2012