A genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese men

Research output: Contribution to journalArticle

Authors

  • KL Ong
  • AWK Tso
  • SS Cherny
  • PC Sham
  • KSL Lam
  • CQ Jiang
  • TH Lams
  • BMY Cheung

Abstract

Fibrinogen, a major determinant of blood viscosity, is an acute phase protein associated with cardiovascular disease. We studied the association of hypertension with single nucleotide polymorphisms (SNPs) in the gene encoding the fibrinogen 13 chain (FGB). Three tagging SNPs (rs1025154, rs4220 and rs1044291) were selected from the HapMap database on Han Chinese. Genotypes were determined in 1,294 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort. There were 199 hypertensive subjects at baseline. Among 1,095 subjects normotensive at baseline, 178 developed hypertension during a median follow-up period of 6.4 years. Among the three tagging SNPs, rs4220 showed significant association with hypertension at both baseline (odds ratio [OR]=1.49, p=0.004) and at follow-up (OR=1.32, p=0.013). The minor A allele of this SNP was associated with higher plasma fibrinogen level (beta=0.144, p

Details

Original languageEnglish
Pages (from-to)728-735
Number of pages8
JournalThrombosis and Haemostasis
Volume103
Issue number4
Publication statusPublished - 1 Apr 2010

Keywords

  • single nucleotide polymorphisms, hypertension, Fibrinogen