TY - JOUR
T1 - A genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese men
AU - Ong, KL
AU - Tso, AWK
AU - Cherny, SS
AU - Sham, PC
AU - Lam, KSL
AU - Jiang, CQ
AU - Thomas, Graham
AU - Lams, TH
AU - Cheung, BMY
PY - 2010/4/1
Y1 - 2010/4/1
N2 - Fibrinogen, a major determinant of blood viscosity, is an acute phase protein associated with cardiovascular disease. We studied the association of hypertension with single nucleotide polymorphisms (SNPs) in the gene encoding the fibrinogen 13 chain (FGB). Three tagging SNPs (rs1025154, rs4220 and rs1044291) were selected from the HapMap database on Han Chinese. Genotypes were determined in 1,294 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort. There were 199 hypertensive subjects at baseline. Among 1,095 subjects normotensive at baseline, 178 developed hypertension during a median follow-up period of 6.4 years. Among the three tagging SNPs, rs4220 showed significant association with hypertension at both baseline (odds ratio [OR]=1.49, p=0.004) and at follow-up (OR=1.32, p=0.013). The minor A allele of this SNP was associated with higher plasma fibrinogen level (beta=0.144, p
AB - Fibrinogen, a major determinant of blood viscosity, is an acute phase protein associated with cardiovascular disease. We studied the association of hypertension with single nucleotide polymorphisms (SNPs) in the gene encoding the fibrinogen 13 chain (FGB). Three tagging SNPs (rs1025154, rs4220 and rs1044291) were selected from the HapMap database on Han Chinese. Genotypes were determined in 1,294 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort. There were 199 hypertensive subjects at baseline. Among 1,095 subjects normotensive at baseline, 178 developed hypertension during a median follow-up period of 6.4 years. Among the three tagging SNPs, rs4220 showed significant association with hypertension at both baseline (odds ratio [OR]=1.49, p=0.004) and at follow-up (OR=1.32, p=0.013). The minor A allele of this SNP was associated with higher plasma fibrinogen level (beta=0.144, p
KW - single nucleotide polymorphisms
KW - hypertension
KW - Fibrinogen
U2 - 10.1160/TH09-10-0692
DO - 10.1160/TH09-10-0692
M3 - Article
C2 - 20135074
VL - 103
SP - 728
EP - 735
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
IS - 4
ER -