A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols

Warwick B Dunn; David Broadhurst; David I Ellis; Marie Brown; Anthony Halsall; Steven O'Hagan; Irena Spasic; Andrew Tseng; Douglas B Kell

doi:10.1093/ije/dym281

A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols

Warwick B Dunn, David Broadhurst, David I Ellis, Marie Brown, Anthony Halsall, Steven O'Hagan, Irena Spasic, Andrew Tseng, Douglas B Kell

Biosciences

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

The stability of mammalian serum and urine in large metabolomic investigations is essential for accurate, valid and reproducible studies. The stability of mammalian serum and urine, either processed immediately by freezing at -80 degrees C or stored at 4 degrees C for 24 h before being frozen, was compared in a pilot metabolomic study of samples from 40 separate healthy volunteers.

Original language	English
Pages (from-to)	i23-30
Journal	International Journal of Epidemiology
Volume	37 Suppl 1
DOIs	https://doi.org/10.1093/ije/dym281
Publication status	Published - Apr 2008

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title = "A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols",

abstract = "The stability of mammalian serum and urine in large metabolomic investigations is essential for accurate, valid and reproducible studies. The stability of mammalian serum and urine, either processed immediately by freezing at -80 degrees C or stored at 4 degrees C for 24 h before being frozen, was compared in a pilot metabolomic study of samples from 40 separate healthy volunteers.",

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AU - Dunn, Warwick B

AU - Broadhurst, David

AU - Ellis, David I

AU - Brown, Marie

AU - Halsall, Anthony

AU - O'Hagan, Steven

AU - Spasic, Irena

AU - Tseng, Andrew

AU - Kell, Douglas B

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N2 - The stability of mammalian serum and urine in large metabolomic investigations is essential for accurate, valid and reproducible studies. The stability of mammalian serum and urine, either processed immediately by freezing at -80 degrees C or stored at 4 degrees C for 24 h before being frozen, was compared in a pilot metabolomic study of samples from 40 separate healthy volunteers.

AB - The stability of mammalian serum and urine in large metabolomic investigations is essential for accurate, valid and reproducible studies. The stability of mammalian serum and urine, either processed immediately by freezing at -80 degrees C or stored at 4 degrees C for 24 h before being frozen, was compared in a pilot metabolomic study of samples from 40 separate healthy volunteers.

U2 - 10.1093/ije/dym281

DO - 10.1093/ije/dym281

M3 - Article

C2 - 18381390

SN - 1464-3685

VL - 37 Suppl 1

SP - i23-30

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

ER -

A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols

Abstract

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