A ferrocenyl-DHIPOH/Cu(OAc)2 complex for diastereo- and enantioselective catalysis of the 1,4-addition of glycine derivatives to alkylidene malonates

Yu-Hua Shi, Zheng Wang, Bin Hu, Ming Wang, John S Fossey, Wei-Ping Deng

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

A planar chiral ferrocene derivative Fc-DHIPOH served as an excellent N,O- chiral ligand for asymmetric copper catalyzed 1,4-addition of glycine derivatives to alkylidene malonates. The corresponding 1,4-adducts were obtained in high yields with excellent enantioselectivities up to 95% ee.
Original languageEnglish
Pages (from-to)6010-3
Number of pages4
JournalOrganic Letters
Volume13
Issue number22
DOIs
Publication statusPublished - 2011

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