A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis

Research output: Contribution to journalArticlepeer-review

Authors

  • Philipp Lutz
  • Cordula Berger
  • Bettina Langhans
  • Frank Grünhage
  • Beate Appenrodt
  • And 7 others
  • Jacob Nattermann
  • Frank Lammert
  • Achim Hoerauf
  • Tilman Sauerbruch
  • Christian P Strassburg
  • Ulrich Spengler
  • Hans Dieter Nischalke

Colleges, School and Institutes

Abstract

BACKGROUND: In mice, the farnesoid X receptor is involved in bacterial translocation, which can result in spontaneous bacterial peritonitis in patients with cirrhosis. We investigated if polymorphisms in the farnesoid X receptor gene influence the risk for spontaneous bacterial peritonitis.

METHODS: Laboratory and clinical data of 293 cirrhotic patients with ascites and 226 healthy controls were prospectively collected. The rs56163822, rs11110390 and rs12313471 polymorphisms of the farnesoid X receptor were determined.

RESULTS: 115 (39%) patients had spontaneous bacterial peritonitis. Distribution of all farnesoid X receptor genotypes matched the Hardy-Weinberg equilibrium. Patients with spontaneous bacterial peritonitis had a higher frequency of the rs56163822 GT genotype (7.0%) than patients without (1.7%, OR=4.4, p=0.02). This genotype was confirmed as predictor of spontaneous bacterial peritonitis by binary logistic regression analysis (OR=6.8, p=0.018).

CONCLUSION: The farnesoid X receptor rs56163822 GT genotype increases the risk for spontaneous bacterial peritonitis in cirrhotic patients with ascites.

Details

Original languageEnglish
Pages (from-to)1047-1050
Number of pages4
JournalDigestive and Liver Disease
Volume46
Issue number11
Early online date30 Jul 2014
Publication statusPublished - Nov 2014

Keywords

  • Adult, Aged, Aged, 80 and over, Ascites, Bacterial Infections, Case-Control Studies, Confidence Intervals, Female, Genetic Predisposition to Disease, Genotype, Humans, Incidence, Liver Cirrhosis, Logistic Models, Male, Middle Aged, Odds Ratio, Peritonitis, Polymorphism, Genetic, Receptors, Cytoplasmic and Nuclear, Reference Values, Risk Assessment, Statistics, Nonparametric, Young Adult, Farnesoid X receptor, Spontaneous bacterial peritonitis