A DNA-binding copper(I) metallo-supramolecular cylinder that can act as an artificial nuclease
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The DNA binding of a dicationic pyridylimine-based dicopper(i) metallosupramolecular cylinder is reported together with its ability to act as an artificial nuclease. The cylinder binds strongly to DNA; more strongly than the spherical dication [Ru(phen)(3)](2+) (phen = 1,10-phenanthroline), but more weakly than the corresponding tetracationic cylinders. DNA coiling effects are not observed with this dication, in contrast to the situation with the previously reported tetracationic cylinder involving a similar ligand. Linear dichroism (LD) data suggests that the dicopper cylinder binds in a different orientation from that of the tetracationic iron cylinder. Furthermore, the dicopper cylinder shows DNA-cleavage activity in the presence of peroxide. Of particular note is that the cylinder displays a marked and unusual ability to cleave both DNA strands at the same site, probably reflecting its dinuclear nature and possibly its mode of binding to the DNA.
|Number of pages||9|
|Journal||Chemistry: A European Journal|
|Publication status||Published - 14 Jun 2006|
- artificial nucleases, copper, DNA cleavage, supramolecular chemistry, bioinorganic chemistry