A core switching strategy to pyrrolo[2,3-b]quinolines and diazocino[1,2-a]indolinones
Research output: Contribution to journal › Article
Colleges, School and Institutes
Two novel core-switching rearrangements to natural product-like privileged scaffolds that proceed in up to 99% yield have been developed. The deviation away from planarity of the central N-acyl urea carbonyl, caused by the structure of the medium-sized ring, dictates the exclusive reaction outcome. Proposed mechanisms and products for the reaction pathways are supported by small molecule X-ray crystallography and an isolated intermediate. Twenty-four novel rearrangement products are reported.
|Journal||Organic and Biomolecular Chemistry|
|Early online date||30 Aug 2016|
|Publication status||Published - 14 Oct 2016|