A concise review of non-alcoholic fatty liver disease

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and the incidence of which is rising rapidly due to the increasing epidemic of obesity in both adults and children. The initial accumulation of fat followed by subsequent inflammation is central to the development of liver damage, and is critically influenced by host factors including age, gender, presence of diabetes, genetic polymorphisms and more recently by the gut microbiome. An increasing body of data suggest that NAFLD is also an independent risk factor of cardiovascular disease, which remains the commonest cause of mortality in such patients. This review focusses on the pathogenesis of NAFLD, and the evolution of new approaches to the management and treatment of NAFLD.

Details

Original languageEnglish
Pages (from-to)192-202
Number of pages11
JournalAtherosclerosis
Volume239
Issue number1
Early online date13 Jan 2015
Publication statusPublished - 1 Mar 2015

Keywords

  • Non-alcoholic fatty liver disease, Pathogenesis, Dyslipidaemia, Insulin resistance, Cardiovascular disease