A comparison of patient and tumour characteristics in two UK bladder cancer cohorts separated by 20 years

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@article{8d9af640bdcd491ba5b28a0a7cdf6039,
title = "A comparison of patient and tumour characteristics in two UK bladder cancer cohorts separated by 20 years",
abstract = "OBJECTIVES: To compare patient and tumour characteristics at presentation from two large bladder cancer cohorts, with recruitment separated by 15-20 years To identify significant differences in the West Midlands' urothelial cancer of the bladder (UCB) population during this period. PATIENTS AND METHODS: Data were collected prospectively from 1478 patients newly diagnosed with UCB in the West Midlands from January 1991 to June 1992 (Cohort 1), and from 1168 patients newly diagnosed with UBC within the same region from December 2005 to April 2011 (Cohort 2). Gender, age, smoking history, and tumour grade, stage, type, multiplicity and size at presentation were compared using a Pearson chi-square test or Cochran-Armitage trend test, as appropriate. RESULT: Cohort 2 had a higher proportion of male patients (P = 0.021), elderly patients (P <0.001), grade 3 tumours (P <0.001), Ta/T1 tumours (P = 0.008), multiple tumours (P <0.001), and tumours of ≤2 cm in diameter (P <0.001). CONCLUSIONS: There were significant differences between the cohorts. These differences are potentially explained by an ageing population, changes in grading practices, improved awareness of important symptoms, improved cystoscopic technology, and reductions in treatment delays. Regional cohorts remain important for identifying changes in tumour and patient characteristics that may influence disease management in the UK and beyond.",
author = "Bryan, {Richard T} and Zeegers, {Maurice P} and {van Roekel}, {Eline H} and Deborah Bird and Grant, {Margaret R} and Dunn, {Janet A} and Sarah Bathers and Gulnaz Iqbal and Khan, {Humera S} and Collins, {Stuart I} and Andrew Howman and Deshmukh, {Nayneeta S} and James, {Nicholas D} and Cheng, {Kar Keung} and Wallace, {D Michael A}",
note = "{\circledC} 2013 BJU International.",
year = "2013",
month = "6",
day = "25",
doi = "10.1111/bju.12032",
language = "English",
volume = "112",
pages = "169--175",
journal = "BJU international",
issn = "1464-4096",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - A comparison of patient and tumour characteristics in two UK bladder cancer cohorts separated by 20 years

AU - Bryan, Richard T

AU - Zeegers, Maurice P

AU - van Roekel, Eline H

AU - Bird, Deborah

AU - Grant, Margaret R

AU - Dunn, Janet A

AU - Bathers, Sarah

AU - Iqbal, Gulnaz

AU - Khan, Humera S

AU - Collins, Stuart I

AU - Howman, Andrew

AU - Deshmukh, Nayneeta S

AU - James, Nicholas D

AU - Cheng, Kar Keung

AU - Wallace, D Michael A

N1 - © 2013 BJU International.

PY - 2013/6/25

Y1 - 2013/6/25

N2 - OBJECTIVES: To compare patient and tumour characteristics at presentation from two large bladder cancer cohorts, with recruitment separated by 15-20 years To identify significant differences in the West Midlands' urothelial cancer of the bladder (UCB) population during this period. PATIENTS AND METHODS: Data were collected prospectively from 1478 patients newly diagnosed with UCB in the West Midlands from January 1991 to June 1992 (Cohort 1), and from 1168 patients newly diagnosed with UBC within the same region from December 2005 to April 2011 (Cohort 2). Gender, age, smoking history, and tumour grade, stage, type, multiplicity and size at presentation were compared using a Pearson chi-square test or Cochran-Armitage trend test, as appropriate. RESULT: Cohort 2 had a higher proportion of male patients (P = 0.021), elderly patients (P <0.001), grade 3 tumours (P <0.001), Ta/T1 tumours (P = 0.008), multiple tumours (P <0.001), and tumours of ≤2 cm in diameter (P <0.001). CONCLUSIONS: There were significant differences between the cohorts. These differences are potentially explained by an ageing population, changes in grading practices, improved awareness of important symptoms, improved cystoscopic technology, and reductions in treatment delays. Regional cohorts remain important for identifying changes in tumour and patient characteristics that may influence disease management in the UK and beyond.

AB - OBJECTIVES: To compare patient and tumour characteristics at presentation from two large bladder cancer cohorts, with recruitment separated by 15-20 years To identify significant differences in the West Midlands' urothelial cancer of the bladder (UCB) population during this period. PATIENTS AND METHODS: Data were collected prospectively from 1478 patients newly diagnosed with UCB in the West Midlands from January 1991 to June 1992 (Cohort 1), and from 1168 patients newly diagnosed with UBC within the same region from December 2005 to April 2011 (Cohort 2). Gender, age, smoking history, and tumour grade, stage, type, multiplicity and size at presentation were compared using a Pearson chi-square test or Cochran-Armitage trend test, as appropriate. RESULT: Cohort 2 had a higher proportion of male patients (P = 0.021), elderly patients (P <0.001), grade 3 tumours (P <0.001), Ta/T1 tumours (P = 0.008), multiple tumours (P <0.001), and tumours of ≤2 cm in diameter (P <0.001). CONCLUSIONS: There were significant differences between the cohorts. These differences are potentially explained by an ageing population, changes in grading practices, improved awareness of important symptoms, improved cystoscopic technology, and reductions in treatment delays. Regional cohorts remain important for identifying changes in tumour and patient characteristics that may influence disease management in the UK and beyond.

U2 - 10.1111/bju.12032

DO - 10.1111/bju.12032

M3 - Article

C2 - 23452262

VL - 112

SP - 169

EP - 175

JO - BJU international

JF - BJU international

SN - 1464-4096

ER -