A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds

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A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds. / Firth, James D.; Craven, Philip G. E.; Lilburn, Matthew; Pahl, Axel; Marsden, Stephen P.; Nelson, Adam.

In: Chemical Communications , Vol. 52, No. 63, 18.07.2016, p. 9837-9840.

Research output: Contribution to journalArticlepeer-review

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Firth, James D. ; Craven, Philip G. E. ; Lilburn, Matthew ; Pahl, Axel ; Marsden, Stephen P. ; Nelson, Adam. / A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds. In: Chemical Communications . 2016 ; Vol. 52, No. 63. pp. 9837-9840.

Bibtex

@article{7a40d370136748778d61ed1d95fa0cca,
title = "A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds",
abstract = "A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.",
author = "Firth, {James D.} and Craven, {Philip G. E.} and Matthew Lilburn and Axel Pahl and Marsden, {Stephen P.} and Adam Nelson",
year = "2016",
month = jul,
day = "18",
doi = "10.1039/C6CC04662B",
language = "English",
volume = "52",
pages = "9837--9840",
journal = "Chemical Communications ",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "63",

}

RIS

TY - JOUR

T1 - A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds

AU - Firth, James D.

AU - Craven, Philip G. E.

AU - Lilburn, Matthew

AU - Pahl, Axel

AU - Marsden, Stephen P.

AU - Nelson, Adam

PY - 2016/7/18

Y1 - 2016/7/18

N2 - A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.

AB - A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.

U2 - 10.1039/C6CC04662B

DO - 10.1039/C6CC04662B

M3 - Article

VL - 52

SP - 9837

EP - 9840

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 63

ER -