Abstract
A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.
Original language | English |
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Pages (from-to) | 9837-9840 |
Journal | Chemical Communications |
Volume | 52 |
Issue number | 63 |
Early online date | 18 Jul 2016 |
DOIs | |
Publication status | E-pub ahead of print - 18 Jul 2016 |