A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds

Research output: Contribution to journalArticlepeer-review


  • James D. Firth
  • Matthew Lilburn
  • Axel Pahl
  • Stephen P. Marsden
  • Adam Nelson

Colleges, School and Institutes


A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.


Original languageEnglish
Pages (from-to)9837-9840
JournalChemical Communications
Issue number63
Early online date18 Jul 2016
Publication statusE-pub ahead of print - 18 Jul 2016