A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.
|Early online date||18 Jul 2016|
|Publication status||E-pub ahead of print - 18 Jul 2016|