5-Chloroindole: a potent allosteric modulator of the 5-HT3 receptor: Allosteric modulation of the 5-HT3receptor

Research output: Contribution to journalArticle

Standard

5-Chloroindole: a potent allosteric modulator of the 5-HT3 receptor : Allosteric modulation of the 5-HT3receptor. / Newman, Amy S; Batis, Nikolaos; Grafton, Gillian; Caputo, Francesca; Brady, Catherine A; Lambert, Jeremy J; Peters, John A; Gordon, John; Brain, Keith L; Powell, Andrew D; Barnes, Nicholas M.

In: British Journal of Pharmacology, Vol. 169, No. 6, 07.2013, p. 1228-1238.

Research output: Contribution to journalArticle

Harvard

APA

Vancouver

Author

Bibtex

@article{edf04d1c40d24782af259f7e6ec961a1,
title = "5-Chloroindole: a potent allosteric modulator of the 5-HT3 receptor: Allosteric modulation of the 5-HT3receptor",
abstract = "The 5-HT3 receptor is a ligand-gated ion channel that is modulated allosterically by various compounds including colchicine, alcohols and volatile anaesthetics. However the positive allosteric modulators (PAMs) identified to date have low affinity, which hinders investigation because of non-selective effects at pharmacologically active concentrations. The present study identifies 5-chloroindole (Cl-indole) as a potent PAM of the 5-HT3 receptor.",
keywords = "5‐HT3 receptor, ligand‐gated ion channel, allosteric modulation",
author = "Newman, {Amy S} and Nikolaos Batis and Gillian Grafton and Francesca Caputo and Brady, {Catherine A} and Lambert, {Jeremy J} and Peters, {John A} and John Gordon and Brain, {Keith L} and Powell, {Andrew D} and Barnes, {Nicholas M}",
note = "{\textcopyright} 2013 The British Pharmacological Society.",
year = "2013",
month = jul
doi = "10.1111/bph.12213",
language = "English",
volume = "169",
pages = "1228--1238",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley",
number = "6",

}

RIS

TY - JOUR

T1 - 5-Chloroindole: a potent allosteric modulator of the 5-HT3 receptor

T2 - Allosteric modulation of the 5-HT3receptor

AU - Newman, Amy S

AU - Batis, Nikolaos

AU - Grafton, Gillian

AU - Caputo, Francesca

AU - Brady, Catherine A

AU - Lambert, Jeremy J

AU - Peters, John A

AU - Gordon, John

AU - Brain, Keith L

AU - Powell, Andrew D

AU - Barnes, Nicholas M

N1 - © 2013 The British Pharmacological Society.

PY - 2013/7

Y1 - 2013/7

N2 - The 5-HT3 receptor is a ligand-gated ion channel that is modulated allosterically by various compounds including colchicine, alcohols and volatile anaesthetics. However the positive allosteric modulators (PAMs) identified to date have low affinity, which hinders investigation because of non-selective effects at pharmacologically active concentrations. The present study identifies 5-chloroindole (Cl-indole) as a potent PAM of the 5-HT3 receptor.

AB - The 5-HT3 receptor is a ligand-gated ion channel that is modulated allosterically by various compounds including colchicine, alcohols and volatile anaesthetics. However the positive allosteric modulators (PAMs) identified to date have low affinity, which hinders investigation because of non-selective effects at pharmacologically active concentrations. The present study identifies 5-chloroindole (Cl-indole) as a potent PAM of the 5-HT3 receptor.

KW - 5‐HT3 receptor

KW - ligand‐gated ion channel

KW - allosteric modulation

U2 - 10.1111/bph.12213

DO - 10.1111/bph.12213

M3 - Article

C2 - 23594147

VL - 169

SP - 1228

EP - 1238

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 6

ER -