5-Chloroindole: a potent allosteric modulator of the 5-HT3 receptor: Allosteric modulation of the 5-HT3receptor
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Colleges, School and Institutes
The 5-HT3 receptor is a ligand-gated ion channel that is modulated allosterically by various compounds including colchicine, alcohols and volatile anaesthetics. However the positive allosteric modulators (PAMs) identified to date have low affinity, which hinders investigation because of non-selective effects at pharmacologically active concentrations. The present study identifies 5-chloroindole (Cl-indole) as a potent PAM of the 5-HT3 receptor.
© 2013 The British Pharmacological Society.
|Number of pages||11|
|Journal||British Journal of Pharmacology|
|Early online date||17 Apr 2013|
|Publication status||Published - Jul 2013|
- 5‐HT3 receptor, ligand‐gated ion channel, allosteric modulation