30 s Response Time of K+ Ion-Selective Hydrogels Functionalized with 18-Crown-6 Ether Based on QCM Sensor

Zhenxiao Zhang; Qian Dou; Hongkai Gao; Bing Bai; Yongmei Zhang; Debo Hu; Ali K. Yetisen; Haider Butt; Xiaoxia Yang; Congju Li; Qing Dai

doi:10.1002/adhm.201700873

30 s Response Time of K⁺ Ion-Selective Hydrogels Functionalized with 18-Crown-6 Ether Based on QCM Sensor

Zhenxiao Zhang, Qian Dou, Hongkai Gao, Bing Bai, Yongmei Zhang, Debo Hu, Ali K. Yetisen, Haider Butt, Xiaoxia Yang, Congju Li, Qing Dai

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Abstract

Potassium detection is critical in monitoring imbalances in electrolytes and physiological status. The development of rapid and robust potassium sensors is desirable in clinical chemistry and point-of-care applications. In this study, composite supramolecular hydrogels are investigated: polyethylene glycol methacrylate and acrylamide copolymer (P(PEGMA-co-AM)) are functionalized with 18-crown-6 ether by employing surface initiated polymerization. Real-time potassium ion monitoring is realized by combining these compounds with quartz crystal microbalance. The device demonstrates a rapid response time of ≈30 s and a concentration detection range from 0.5 to 7.0 × 10-3 m. These hydrogels also exhibit high reusability and K+ ion selectivity relative to other cations in biofluids such as Na+ , NH4+ , Mg2+ , and Ca2+ . These results provide a new approach for sensing alkali metal ions using P(PEGMA-co-AM) hydrogels.

Original language	English
Journal	Advanced Healthcare Materials
Early online date	6 Dec 2017
DOIs	https://doi.org/10.1002/adhm.201700873
Publication status	E-pub ahead of print - 6 Dec 2017

Keywords

Journal Article
potassium detection
QCM sensors
supramolecular hydrogels

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10.1002/adhm.201700873Licence: None: All rights reserved

Zhang_et_al_30s_response_time_of_K+_Advanced_Healthcare_Materials_2017
This is the peer reviewed version of the following article: Z. X. Zhang, Q. Dou, H. K. Gao, B. Bai, Y. M. Zhang, D. B. Hu, A. K. Yetisen, H. Butt, X. X. Yang, C. J. Li, Q. Dai, Adv. Healthcare Mater. 2017, 1700873. https://doi.org/10.1002/adhm.201700873, which has been published in final form at 10.1002/adhm.201700873. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 1.05 MBLicence: Other (please specify with Rights Statement)

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Cite this

@article{3e0ab06c10b74d44a19b29f833010191,

title = "30 s Response Time of K+ Ion-Selective Hydrogels Functionalized with 18-Crown-6 Ether Based on QCM Sensor",

abstract = "Potassium detection is critical in monitoring imbalances in electrolytes and physiological status. The development of rapid and robust potassium sensors is desirable in clinical chemistry and point-of-care applications. In this study, composite supramolecular hydrogels are investigated: polyethylene glycol methacrylate and acrylamide copolymer (P(PEGMA-co-AM)) are functionalized with 18-crown-6 ether by employing surface initiated polymerization. Real-time potassium ion monitoring is realized by combining these compounds with quartz crystal microbalance. The device demonstrates a rapid response time of ≈30 s and a concentration detection range from 0.5 to 7.0 × 10-3 m. These hydrogels also exhibit high reusability and K+ ion selectivity relative to other cations in biofluids such as Na+ , NH4+ , Mg2+ , and Ca2+ . These results provide a new approach for sensing alkali metal ions using P(PEGMA-co-AM) hydrogels.",

keywords = "Journal Article, potassium detection, QCM sensors , supramolecular hydrogels",

author = "Zhenxiao Zhang and Qian Dou and Hongkai Gao and Bing Bai and Yongmei Zhang and Debo Hu and Yetisen, {Ali K.} and Haider Butt and Xiaoxia Yang and Congju Li and Qing Dai",

note = "{\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2017",

month = dec,

day = "6",

doi = "10.1002/adhm.201700873",

language = "English",

journal = "Advanced Healthcare Materials",

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T1 - 30 s Response Time of K+ Ion-Selective Hydrogels Functionalized with 18-Crown-6 Ether Based on QCM Sensor

AU - Zhang, Zhenxiao

AU - Dou, Qian

AU - Gao, Hongkai

AU - Bai, Bing

AU - Zhang, Yongmei

AU - Hu, Debo

AU - Yetisen, Ali K.

AU - Butt, Haider

AU - Yang, Xiaoxia

AU - Li, Congju

AU - Dai, Qing

PY - 2017/12/6

Y1 - 2017/12/6

N2 - Potassium detection is critical in monitoring imbalances in electrolytes and physiological status. The development of rapid and robust potassium sensors is desirable in clinical chemistry and point-of-care applications. In this study, composite supramolecular hydrogels are investigated: polyethylene glycol methacrylate and acrylamide copolymer (P(PEGMA-co-AM)) are functionalized with 18-crown-6 ether by employing surface initiated polymerization. Real-time potassium ion monitoring is realized by combining these compounds with quartz crystal microbalance. The device demonstrates a rapid response time of ≈30 s and a concentration detection range from 0.5 to 7.0 × 10-3 m. These hydrogels also exhibit high reusability and K+ ion selectivity relative to other cations in biofluids such as Na+ , NH4+ , Mg2+ , and Ca2+ . These results provide a new approach for sensing alkali metal ions using P(PEGMA-co-AM) hydrogels.

AB - Potassium detection is critical in monitoring imbalances in electrolytes and physiological status. The development of rapid and robust potassium sensors is desirable in clinical chemistry and point-of-care applications. In this study, composite supramolecular hydrogels are investigated: polyethylene glycol methacrylate and acrylamide copolymer (P(PEGMA-co-AM)) are functionalized with 18-crown-6 ether by employing surface initiated polymerization. Real-time potassium ion monitoring is realized by combining these compounds with quartz crystal microbalance. The device demonstrates a rapid response time of ≈30 s and a concentration detection range from 0.5 to 7.0 × 10-3 m. These hydrogels also exhibit high reusability and K+ ion selectivity relative to other cations in biofluids such as Na+ , NH4+ , Mg2+ , and Ca2+ . These results provide a new approach for sensing alkali metal ions using P(PEGMA-co-AM) hydrogels.

KW - Journal Article

KW - potassium detection

KW - QCM sensors

KW - supramolecular hydrogels

U2 - 10.1002/adhm.201700873

DO - 10.1002/adhm.201700873

M3 - Article

C2 - 29210514

SN - 2192-2640

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

ER -