2,7-Diazabicyclo[2.2.1]heptanes: novel asymmetric access and controlled bridge-opening

Gary Peczkowski; Philip Craven; Darren Stead; Nigel Simpkins

doi:10.1039/c8cc10263e

2,7-Diazabicyclo[2.2.1]heptanes: novel asymmetric access and controlled bridge-opening

Gary Peczkowski, Philip Craven, Darren Stead, Nigel Simpkins

Chemistry

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

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Abstract

Organocatalysed asymmetric Michael additions of substituted triketopiperazines to enones afford products in high yield and enantiomeric ratio (er). Further modification delivers products possessing natural product (NP) scaffolds including diazabicyclo[2.2.1]heptane, prolinamide and harmicine.

Original language	English
Pages (from-to)	4214-4217
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	29
DOIs	https://doi.org/10.1039/c8cc10263e
Publication status	Published - 12 Mar 2019

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c8cc10263eLicence: Creative Commons: Attribution-NonCommercial (CC BY-NC)

Gary_Peczkowski_et_al_2,7_Diazabicyclo[2.2.1]heptanes_Chemical_Communications_2019
Checked for eligibility: 05/04/2019
Final published version, 1.9 MBLicence: Creative Commons: Attribution-NonCommercial (CC BY-NC)

Cite this

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abstract = "Organocatalysed asymmetric Michael additions of substituted triketopiperazines to enones afford products in high yield and enantiomeric ratio (er). Further modification delivers products possessing natural product (NP) scaffolds including diazabicyclo[2.2.1]heptane, prolinamide and harmicine.",

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AU - Stead, Darren

AU - Simpkins, Nigel

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AB - Organocatalysed asymmetric Michael additions of substituted triketopiperazines to enones afford products in high yield and enantiomeric ratio (er). Further modification delivers products possessing natural product (NP) scaffolds including diazabicyclo[2.2.1]heptane, prolinamide and harmicine.

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2,7-Diazabicyclo[2.2.1]heptanes: novel asymmetric access and controlled bridge-opening

Abstract

ASJC Scopus subject areas

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