2,7-Diazabicyclo[2.2.1]heptanes: novel asymmetric access and controlled bridge-opening

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

External organisations

  • Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK

Abstract

Organocatalysed asymmetric Michael additions of substituted triketopiperazines to enones afford products in high yield and enantiomeric ratio (er). Further modification delivers products possessing natural product (NP) scaffolds including diazabicyclo[2.2.1]heptane, prolinamide and harmicine.

Details

Original languageEnglish
Pages (from-to)4214-4217
Number of pages4
JournalChemical Communications
Volume55
Issue number29
Publication statusPublished - 12 Mar 2019