25-hydroxyvitamin D deficiency is associated with increased aortic stiffness in patients with systemic lupus erythematosus

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25-hydroxyvitamin D deficiency is associated with increased aortic stiffness in patients with systemic lupus erythematosus. / Reynolds, John A.; Haque, Sahena; Berry, Jacqueline L.; Pemberton, Philip; Teh, Lee Suan; Ho, Pauline; Gorodkin, Rachel; Bruce, Ian N.

In: Rheumatology, Vol. 51, No. 3, ker352, 01.03.2012, p. 544-551.

Research output: Contribution to journalArticle

Harvard

Reynolds, JA, Haque, S, Berry, JL, Pemberton, P, Teh, LS, Ho, P, Gorodkin, R & Bruce, IN 2012, '25-hydroxyvitamin D deficiency is associated with increased aortic stiffness in patients with systemic lupus erythematosus', Rheumatology, vol. 51, no. 3, ker352, pp. 544-551. https://doi.org/10.1093/rheumatology/ker352

APA

Reynolds, J. A., Haque, S., Berry, J. L., Pemberton, P., Teh, L. S., Ho, P., Gorodkin, R., & Bruce, I. N. (2012). 25-hydroxyvitamin D deficiency is associated with increased aortic stiffness in patients with systemic lupus erythematosus. Rheumatology, 51(3), 544-551. [ker352]. https://doi.org/10.1093/rheumatology/ker352

Vancouver

Author

Reynolds, John A. ; Haque, Sahena ; Berry, Jacqueline L. ; Pemberton, Philip ; Teh, Lee Suan ; Ho, Pauline ; Gorodkin, Rachel ; Bruce, Ian N. / 25-hydroxyvitamin D deficiency is associated with increased aortic stiffness in patients with systemic lupus erythematosus. In: Rheumatology. 2012 ; Vol. 51, No. 3. pp. 544-551.

Bibtex

@article{0f47cef9a9f44e56898a1ee1006a5be0,
title = "25-hydroxyvitamin D deficiency is associated with increased aortic stiffness in patients with systemic lupus erythematosus",
abstract = "Objective: To determine the relationship between serum vitamin D and markers of subclinical cardiovascular disease (CVD) in patients with SLE. Methods: We recruited SLE patients (≥4 ACR 1997 criteria) from outpatient clinics between January 2007 and January 2009. Vitamin D deficiency was defined as serum 25(OH)D <20 ng/ml measured by ELISA. Disease activity was measured using the SLEDAI-2K score. Aortic pulse wave velocity (aPWV) was measured using PulseTrace 3600 (Micromedical) and carotid plaque (CP) and intima-media thickness (IMT) assessed using B-mode Doppler US. Results: Seventy-five women with SLE were recruited with a median (interquartile range) disease duration of 16 (8-27) years. Patients with vitamin D deficiency had higher BMI (P = 0.014) and insulin resistance (P = 0.023) than those with 25(OH)D >20 ng/ml. Subjects with SLEDAI-2K ≥4 had lower 25(OH)D than those with SLEDAI-2K <4 (median 12.9 vs 20.3 ng/ml, P = 0.031). Aortic stiffness was significantly associated with serum 25(OH)D [log(aPWV) β (95% CI) -0.0217 (-0.038, -0.005), P = 0.010] independently of BMI, CVD risk factors and serum insulin. Adjustment for disease activity reduced the strength of the association. There was no association between 25(OH)D and CP or IMT. Conclusions: Vitamin D deficiency is associated with increased aortic stiffness in SLE, independent of CVD risk factors and insulin. Increased inflammatory disease activity may be the mechanism by which vitamin D deficiency mediates vascular stiffness in this patient group.",
keywords = "Cardiovascular risk, Disease activity, Systemic lupus erythematosus, Vascular stiffness, Vitamin D",
author = "Reynolds, {John A.} and Sahena Haque and Berry, {Jacqueline L.} and Philip Pemberton and Teh, {Lee Suan} and Pauline Ho and Rachel Gorodkin and Bruce, {Ian N.}",
year = "2012",
month = mar,
day = "1",
doi = "10.1093/rheumatology/ker352",
language = "English",
volume = "51",
pages = "544--551",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - 25-hydroxyvitamin D deficiency is associated with increased aortic stiffness in patients with systemic lupus erythematosus

AU - Reynolds, John A.

AU - Haque, Sahena

AU - Berry, Jacqueline L.

AU - Pemberton, Philip

AU - Teh, Lee Suan

AU - Ho, Pauline

AU - Gorodkin, Rachel

AU - Bruce, Ian N.

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Objective: To determine the relationship between serum vitamin D and markers of subclinical cardiovascular disease (CVD) in patients with SLE. Methods: We recruited SLE patients (≥4 ACR 1997 criteria) from outpatient clinics between January 2007 and January 2009. Vitamin D deficiency was defined as serum 25(OH)D <20 ng/ml measured by ELISA. Disease activity was measured using the SLEDAI-2K score. Aortic pulse wave velocity (aPWV) was measured using PulseTrace 3600 (Micromedical) and carotid plaque (CP) and intima-media thickness (IMT) assessed using B-mode Doppler US. Results: Seventy-five women with SLE were recruited with a median (interquartile range) disease duration of 16 (8-27) years. Patients with vitamin D deficiency had higher BMI (P = 0.014) and insulin resistance (P = 0.023) than those with 25(OH)D >20 ng/ml. Subjects with SLEDAI-2K ≥4 had lower 25(OH)D than those with SLEDAI-2K <4 (median 12.9 vs 20.3 ng/ml, P = 0.031). Aortic stiffness was significantly associated with serum 25(OH)D [log(aPWV) β (95% CI) -0.0217 (-0.038, -0.005), P = 0.010] independently of BMI, CVD risk factors and serum insulin. Adjustment for disease activity reduced the strength of the association. There was no association between 25(OH)D and CP or IMT. Conclusions: Vitamin D deficiency is associated with increased aortic stiffness in SLE, independent of CVD risk factors and insulin. Increased inflammatory disease activity may be the mechanism by which vitamin D deficiency mediates vascular stiffness in this patient group.

AB - Objective: To determine the relationship between serum vitamin D and markers of subclinical cardiovascular disease (CVD) in patients with SLE. Methods: We recruited SLE patients (≥4 ACR 1997 criteria) from outpatient clinics between January 2007 and January 2009. Vitamin D deficiency was defined as serum 25(OH)D <20 ng/ml measured by ELISA. Disease activity was measured using the SLEDAI-2K score. Aortic pulse wave velocity (aPWV) was measured using PulseTrace 3600 (Micromedical) and carotid plaque (CP) and intima-media thickness (IMT) assessed using B-mode Doppler US. Results: Seventy-five women with SLE were recruited with a median (interquartile range) disease duration of 16 (8-27) years. Patients with vitamin D deficiency had higher BMI (P = 0.014) and insulin resistance (P = 0.023) than those with 25(OH)D >20 ng/ml. Subjects with SLEDAI-2K ≥4 had lower 25(OH)D than those with SLEDAI-2K <4 (median 12.9 vs 20.3 ng/ml, P = 0.031). Aortic stiffness was significantly associated with serum 25(OH)D [log(aPWV) β (95% CI) -0.0217 (-0.038, -0.005), P = 0.010] independently of BMI, CVD risk factors and serum insulin. Adjustment for disease activity reduced the strength of the association. There was no association between 25(OH)D and CP or IMT. Conclusions: Vitamin D deficiency is associated with increased aortic stiffness in SLE, independent of CVD risk factors and insulin. Increased inflammatory disease activity may be the mechanism by which vitamin D deficiency mediates vascular stiffness in this patient group.

KW - Cardiovascular risk

KW - Disease activity

KW - Systemic lupus erythematosus

KW - Vascular stiffness

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=84857543005&partnerID=8YFLogxK

U2 - 10.1093/rheumatology/ker352

DO - 10.1093/rheumatology/ker352

M3 - Article

C2 - 22120462

AN - SCOPUS:84857543005

VL - 51

SP - 544

EP - 551

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 3

M1 - ker352

ER -