11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in Idiopathic intracranial hypertension

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  Assessing the Therapeutic Efficacy of an 11Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in Idiopathic Intracranial Hypertension (IIH)

  Sinclair, A., Tomlinson, J. & Stewart, P.

  Medical Research Council

  12/08/13 → 11/08/17

  Project: Research Councils

  • Pseudotumor Cerebri 100%
  • Intracranial Pressure 30%
  • Headache 20%
  • 11-beta-Hydroxysteroid Dehydrogenases 19%
  • 2-(1-(5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl)-3-piperidyl)acetic acid 14%

• Sustained treatment of Idiopathic Intracranial Hypertension (IIH) through weight loss induced by bariatric surgery

  Sinclair, A.

  NIHR TRAINEES COORDINATING CENTRE

  1/06/13 → 31/10/18

  Project: Research

  • Pseudotumor Cerebri 100%
  • Intracranial Pressure 33%
  • Headache 19%
  • 2-(1-(5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl)-3-piperidyl)acetic acid 17%
  • Bariatric Surgery 15%