γδ TCR Recognition of MR1: Adapting to Life on the Flip Side
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental differences in γδ T cell recognition.
|Number of pages||3|
|Journal||Trends in Biochemical Sciences|
|Early online date||13 Apr 2020|
|Publication status||Published - 1 Jul 2020|