γδ TCR Recognition of MR1: Adapting to Life on the Flip Side

Research output: Contribution to journalArticlepeer-review

Colleges, School and Institutes

Abstract

Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental differences in γδ T cell recognition.

Details

Original languageEnglish
Pages (from-to)551-553
Number of pages3
JournalTrends in Biochemical Sciences
Volume45
Issue number7
Early online date13 Apr 2020
Publication statusPublished - 1 Jul 2020