Projects per year
Abstract
Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental differences in γδ T cell recognition.
Original language | English |
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Pages (from-to) | 551-553 |
Number of pages | 3 |
Journal | Trends in Biochemical Sciences |
Volume | 45 |
Issue number | 7 |
Early online date | 13 Apr 2020 |
DOIs | |
Publication status | Published - 1 Jul 2020 |
Keywords
- T cell receptor (TCR)
- complementarity determining region (CDR)
- gamma delta
- major histocompatibility complex (MHC)
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
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Dive into the research topics of 'γδ TCR Recognition of MR1: Adapting to Life on the Flip Side'. Together they form a unique fingerprint.Projects
- 2 Finished
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The Molecular Basis of Gamma Delta T Cell Recognition in Health and Disease
1/06/13 → 31/05/21
Project: Research